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In the case of sporadic or late-onset AD, which accounts for greater than 95% of cases, several genes are implicated in increasing the risk, but whether they also cause the disease by altering amyloid levels is currently unknown. Through loss of function studies in a model cell line, here RNAi-mediated silencing of several late onset AD genes affected A\u03b2 levels is shown. However, unlike the genes underlying familial AD, late onset AD-susceptibility genes do not specifically alter the A\u03b242\/40 ratios and suggest that these genes probably contribute to AD through distinct mechanisms.<\/jats:p>","DOI":"10.1073\/pnas.1201632109","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T20:17:32Z","timestamp":1346789852000},"page":"15307-15311","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["Role of genes linked to sporadic Alzheimer\u2019s disease risk in the production of \u03b2-amyloid peptides"],"prefix":"10.1073","volume":"109","author":[{"given":"Jitin","family":"Bali","sequence":"first","affiliation":[{"name":"Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, and"},{"name":"Graduate Program in Neuroscience Center Zurich, University of Zurich, 8008 Zurich, 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