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Genetic disruption of\n                    <jats:italic>SRC-3<\/jats:italic>\n                    in mice results in a pleiotropic phenotype showing dwarfism, delayed puberty, reduced female reproductive function, and blunted mammary gland development. Hormonal analysis indicates that SRC-3 plays a role in both the growth hormone regulatory pathway and the production of estrogen, which may explain the observed phenotypes. These results suggest that the physiological role of SRC-3 is different from that of SRC-1 and prove the diversity among coactivator family members.\n                  <\/jats:p>","DOI":"10.1073\/pnas.120166297","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"6379-6384","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":429,"title":["The steroid receptor coactivator SRC-3 (p\/CIP\/RAC3\/AIB1\/ACTR\/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development"],"prefix":"10.1073","volume":"97","author":[{"given":"Jianming","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; and Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030; 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