{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:52:58Z","timestamp":1790805178437,"version":"4.1.0"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"34","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2012,8,21]]},"abstract":"<jats:p>\n                    Many tumors are characterized by recurrent translocations between a tissue-specific gene and a proto-oncogene. The juxtaposition of the Ig heavy chain gene and\n                    <jats:italic>Myc<\/jats:italic>\n                    in Burkitt\u2019s lymphoma and in murine plasmacytoma is a classic example. Regulatory elements within the heavy chain constant region locus are required for\n                    <jats:italic>Myc<\/jats:italic>\n                    translocation and\/or deregulation. However, many genes are regulated by cis-acting elements at distances up to 1,000 kb outside the locus. Such putative distal elements have not been examined for the heavy chain locus, particularly in the context of\n                    <jats:italic>Myc<\/jats:italic>\n                    translocations. We demonstrate that a transgene containing the Ig heavy chain constant region locus, inserted into five different chromosomal locations, can undergo translocations involving\n                    <jats:italic>Myc<\/jats:italic>\n                    . Furthermore, these translocations are able to generate plasmacytomas in each transgenic line. We conclude that the heavy chain constant region locus itself includes all of the elements necessary for both the translocation and the deregulation of the proto-oncogene.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1202882109","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T22:50:06Z","timestamp":1344293406000},"page":"13728-13732","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Oncogenic\n                    <i>Myc<\/i>\n                    translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus"],"prefix":"10.1073","volume":"109","author":[{"given":"Elizabeth","family":"Spehalski","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genqing","family":"Liang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Dubois","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Herbert. C.","family":"Morse","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-2200;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Casellas","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley A.","family":"Dunnick","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2012,8,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2010.03.016","article-title":"Origin of chromosomal translocations in lymphoid cancer","volume":"141","author":"Nussenzweig A","year":"2010","unstructured":"A Nussenzweig, MC Nussenzweig, Origin of chromosomal translocations in lymphoid cancer. Cell 141, 27\u201338 (2010).","journal-title":"Cell"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-immunol-031210-101329","article-title":"Mechanisms that promote and suppress chromosomal translocations in lymphocytes","volume":"29","author":"Gostissa M","year":"2011","unstructured":"M Gostissa, FW Alt, R Chiarle, Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol 29, 319\u2013350 (2011).","journal-title":"Annu Rev Immunol"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-230X(08)60200-6","article-title":"Activation of cellular oncogenes in hemopoietic cells by chromosome translocation","volume":"47","author":"Cory S","year":"1986","unstructured":"S Cory, Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. Adv Cancer Res 47, 189\u2013234 (1986).","journal-title":"Adv Cancer Res"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1034\/j.1600-065X.2003.00061.x","article-title":"Neoplastic development in plasma cells","volume":"194","author":"Potter M","year":"2003","unstructured":"M Potter, Neoplastic development in plasma cells. Immunol Rev 194, 177\u2013195 (2003).","journal-title":"Immunol Rev"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.dnarep.2006.05.017","article-title":"Myc translocations in B cell and plasma cell neoplasms","volume":"5","author":"Janz S","year":"2006","unstructured":"S Janz, Myc translocations in B cell and plasma cell neoplasms. DNA Repair (Amst) 5, 1213\u20131224 (2006).","journal-title":"DNA Repair (Amst)"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1038\/sj.onc.1204640","article-title":"Mechanisms of chromosomal translocations in B cell lymphomas","volume":"20","author":"K\u00fcppers R","year":"2001","unstructured":"R K\u00fcppers, R Dalla-Favera, Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580\u20135594 (2001).","journal-title":"Oncogene"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/B978-012053641-2\/50020-4","volume-title":"Molecular Biology of B Cells","author":"Cogne M","year":"2004","unstructured":"M Cogne, BK Birshtein Molecular Biology of B Cells, eds T Honjo, FW Alt, MS Neuberger (Academic, London), pp. 289\u2013305 (2004)."},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1073\/pnas.0812763106","article-title":"Chromosomal location targets different MYC family gene members for oncogenic translocations","volume":"106","author":"Gostissa M","year":"2009","unstructured":"M Gostissa, S Ranganath, JM Bianco, FW Alt, Chromosomal location targets different MYC family gene members for oncogenic translocations. Proc Natl Acad Sci USA 106, 2265\u20132270 (2009).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1084\/jem.20070882","article-title":"AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig\/Myc chromosomal rearrangements","volume":"204","author":"Kovalchuk AL","year":"2007","unstructured":"AL Kovalchuk, et al., AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig\/Myc chromosomal rearrangements. J Exp Med 204, 2989\u20133001 (2007).","journal-title":"J Exp Med"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1073\/pnas.0308757101","article-title":"Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells","volume":"101","author":"Rooney S","year":"2004","unstructured":"S Rooney, et al., Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci USA 101, 2410\u20132415 (2004).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1471-4906(01)02111-1","article-title":"Mechanism and control of class-switch recombination","volume":"23","author":"Manis JP","year":"2002","unstructured":"JP Manis, M Tian, FW Alt, Mechanism and control of class-switch recombination. Trends Immunol 23, 31\u201339 (2002).","journal-title":"Trends Immunol"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu M","year":"2000","unstructured":"M Muramatsu, et al., Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553\u2013563 (2000).","journal-title":"Cell"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)00079-9","article-title":"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)","volume":"102","author":"Revy P","year":"2000","unstructured":"P Revy, et al., Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102, 565\u2013575 (2000).","journal-title":"Cell"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cell.2004.08.006","article-title":"AID is required for c-myc\/IgH chromosome translocations in vivo","volume":"118","author":"Ramiro AR","year":"2004","unstructured":"AR Ramiro, et al., AID is required for c-myc\/IgH chromosome translocations in vivo. Cell 118, 431\u2013438 (2004).","journal-title":"Cell"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1084\/jem.20070884","article-title":"A role for AID in chromosome translocations between c-myc and the IgH variable region","volume":"204","author":"Dorsett Y","year":"2007","unstructured":"Y Dorsett, et al., A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med 204, 2225\u20132232 (2007).","journal-title":"J Exp Med"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.cell.2008.09.062","article-title":"AID is required for the chromosomal breaks in c-myc that lead to c-myc\/IgH translocations","volume":"135","author":"Robbiani DF","year":"2008","unstructured":"DF Robbiani, et al., AID is required for the chromosomal breaks in c-myc that lead to c-myc\/IgH translocations. Cell 135, 1028\u20131038 (2008).","journal-title":"Cell"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nature08633","article-title":"Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3\u2032 regulatory region","volume":"462","author":"Gostissa M","year":"2009","unstructured":"M Gostissa, et al., Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3\u2032 regulatory region. Nature 462, 803\u2013807 (2009).","journal-title":"Nature"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1084\/jem.20091280","article-title":"Switch recombination and somatic hypermutation are controlled by the heavy chain 3\u2032 enhancer region","volume":"206","author":"Dunnick WA","year":"2009","unstructured":"WA Dunnick, et al., Switch recombination and somatic hypermutation are controlled by the heavy chain 3\u2032 enhancer region. J Exp Med 206, 2613\u20132623 (2009).","journal-title":"J Exp Med"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"7361","DOI":"10.1073\/pnas.90.15.7361","article-title":"Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction","volume":"90","author":"Janz S","year":"1993","unstructured":"S Janz, J M\u00fcller, J Shaughnessy, M Potter, Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. Proc Natl Acad Sci USA 90, 7361\u20137365 (1993).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature04495","article-title":"Role of genomic instability and p53 in AID-induced c-myc-Igh translocations","volume":"440","author":"Ramiro AR","year":"2006","unstructured":"AR Ramiro, et al., Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440, 105\u2013109 (2006).","journal-title":"Nature"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng1196-312","article-title":"Multicolor spectral karyotyping of mouse chromosomes","volume":"14","author":"Liyanage M","year":"2004","unstructured":"M Liyanage, et al., Multicolor spectral karyotyping of mouse chromosomes. Nat Genet 14, 312\u2013315 (2004).","journal-title":"Nat Genet"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/312777a0","article-title":"Variant (6; 15) translocation in a murine plasmacytoma occurs near an immunoglobulin \u03ba gene but far from the myc oncogene","volume":"312","author":"Webb E","year":"1984","unstructured":"E Webb, JM Adams, S Cory, Variant (6; 15) translocation in a murine plasmacytoma occurs near an immunoglobulin \u03ba gene but far from the myc oncogene. Nature 312, 777\u2013779 (1984).","journal-title":"Nature"},{"key":"e_1_3_4_23_2","first-page":"67","article-title":"Structure and expression of the c-Myc\/Pvt 1 megagene locus","volume":"224","author":"Siwarski D","year":"1997","unstructured":"D Siwarski, et al., Structure and expression of the c-Myc\/Pvt 1 megagene locus. Curr Top Microbiol Immunol 224, 67\u201372 (1997).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ni.1964","article-title":"Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes","volume":"12","author":"Yamane A","year":"2011","unstructured":"A Yamane, et al., Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12, 62\u201369 (2011).","journal-title":"Nat Immunol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/15376516.2011.562759","article-title":"Genomic instability and mouse microRNAs","volume":"21","author":"Huppi K","year":"2011","unstructured":"K Huppi, J Pitt, B Wahlberg, NJ Caplen, Genomic instability and mouse microRNAs. Toxicol Mech Methods 21, 325\u2013333 (2011).","journal-title":"Toxicol Mech Methods"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cell.2011.07.048","article-title":"Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes","volume":"147","author":"Klein IA","year":"2011","unstructured":"IA Klein, et al., Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 147, 95\u2013106 (2011).","journal-title":"Cell"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2011.07.049","article-title":"Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells","volume":"147","author":"Chiarle R","year":"2011","unstructured":"R Chiarle, et al., Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell 147, 107\u2013119 (2011).","journal-title":"Cell"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.4049\/jimmunol.173.9.5531","article-title":"Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: Effect of a mutation in a STAT6 binding site in the \u03b3 1 promoter","volume":"173","author":"Dunnick WA","year":"2004","unstructured":"WA Dunnick, J Shi, KA Graves, JT Collins, Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: Effect of a mutation in a STAT6 binding site in the \u03b3 1 promoter. J Immunol 173, 5531\u20135539 (2004).","journal-title":"J Immunol"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature10909","article-title":"DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes","volume":"484","author":"Hakim O","year":"2012","unstructured":"O Hakim, et al., DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature 484, 69\u201374 (2012).","journal-title":"Nature"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ni.1909","article-title":"Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination","volume":"11","author":"Hasham MG","year":"2010","unstructured":"MG Hasham, et al., Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 11, 820\u2013826 (2010).","journal-title":"Nat Immunol"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.cell.2012.02.002","article-title":"Spatial organization of the mouse genome and its role in recurrent chromosomal translocations","volume":"148","author":"Zhang Y","year":"2012","unstructured":"Y Zhang, et al., Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell 148, 908\u2013921 (2012).","journal-title":"Cell"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.semcancer.2006.10.008","article-title":"Spatial genome organization in the formation of chromosomal translocations","volume":"17","author":"Meaburn KJ","year":"2007","unstructured":"KJ Meaburn, T Misteli, E Soutoglou, Spatial genome organization in the formation of chromosomal translocations. Semin Cancer Biol 17, 80\u201390 (2007).","journal-title":"Semin Cancer Biol"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/S0960-9822(02)01166-1","article-title":"Conservation of relative chromosome positioning in normal and cancer cells","volume":"12","author":"Parada LA","year":"2002","unstructured":"LA Parada, PG McQueen, PJ Munson, T Misteli, Conservation of relative chromosome positioning in normal and cancer cells. Curr Biol 12, 1692\u20131697 (2002).","journal-title":"Curr Biol"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/ng1177","article-title":"Spatial proximity of translocation-prone gene loci in human lymphomas","volume":"34","author":"Roix JJ","year":"2003","unstructured":"JJ Roix, PG McQueen, PJ Munson, LA Parada, T Misteli, Spatial proximity of translocation-prone gene loci in human lymphomas. Nat Genet 34, 287\u2013291 (2003).","journal-title":"Nat Genet"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"e192","DOI":"10.1371\/journal.pbio.0050192","article-title":"Myc dynamically and preferentially relocates to a transcription factory occupied by Igh","volume":"5","author":"Osborne CS","year":"2007","unstructured":"CS Osborne, et al., Myc dynamically and preferentially relocates to a transcription factory occupied by Igh. PLoS Biol 5, e192 (2007).","journal-title":"PLoS Biol"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature06547","article-title":"Two levels of protection for the B cell genome during somatic hypermutation","volume":"451","author":"Liu M","year":"2008","unstructured":"M Liu, et al., Two levels of protection for the B cell genome during somatic hypermutation. Nature 451, 841\u2013845 (2008).","journal-title":"Nature"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1101\/gad.8.18.2212","article-title":"Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt\u2019s lymphoma cells","volume":"8","author":"Madisen L","year":"1994","unstructured":"L Madisen, M Groudine, Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt\u2019s lymphoma cells. Genes Dev 8, 2212\u20132226 (1994).","journal-title":"Genes Dev"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.4049\/jimmunol.179.9.6033","article-title":"The 3\u2032 IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype","volume":"179","author":"Truffinet V","year":"2007","unstructured":"V Truffinet, et al., The 3\u2032 IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype. J Immunol 179, 6033\u20136042 (2007).","journal-title":"J Immunol"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1038\/sj.onc.1210061","article-title":"The immunoglobulin heavy-chain gene 3\u2032 enhancers deregulate bcl-2 promoter usage in t(14;18) lymphoma cells","volume":"26","author":"Duan H","year":"2007","unstructured":"H Duan, CA Heckman, LM Boxer, The immunoglobulin heavy-chain gene 3\u2032 enhancers deregulate bcl-2 promoter usage in t(14;18) lymphoma cells. Oncogene 26, 2635\u20132641 (2007).","journal-title":"Oncogene"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1074-7613(00)80395-7","article-title":"Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification","volume":"7","author":"Pelanda R","year":"1997","unstructured":"R Pelanda, et al., Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification. Immunity 7, 765\u2013775 (1997).","journal-title":"Immunity"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.183.2.381","article-title":"bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice","volume":"183","author":"Grillot DAM","year":"1996","unstructured":"DAM Grillot, et al., bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med 183, 381\u2013391 (1996).","journal-title":"J Exp Med"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1202882109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T04:51:01Z","timestamp":1654577461000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1202882109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,6]]},"references-count":41,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2012,8,21]]}},"alternative-id":["10.1073\/pnas.1202882109"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1202882109","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,6]]},"assertion":[{"value":"2012-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}