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Studies of eight lncRNAs with 2- to &gt;100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5\u20131.3 h). Light exposure at night rapidly reverses (halving time = 9\u201332 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.<\/jats:p>","DOI":"10.1073\/pnas.1207748109","type":"journal-article","created":{"date-parts":[[2012,8,4]],"date-time":"2012-08-04T01:06:39Z","timestamp":1344042399000},"page":"13319-13324","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["Circadian changes in long noncoding RNAs in the pineal gland"],"prefix":"10.1073","volume":"109","author":[{"given":"Steven L.","family":"Coon","sequence":"first","affiliation":[{"name":"Section on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Munson","sequence":"additional","affiliation":[{"name":"Mathematical and Statistical Computing Laboratory, Center for Information Technology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen F.","family":"Cherukuri","sequence":"additional","affiliation":[{"name":"Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"National Institutes of Health Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Rockville, MD 20852;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sugden","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, School of Medicine, King\u2019s College London, London SE1 1UL, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J. 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