{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:52:56Z","timestamp":1790229176555,"version":"4.1.0"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:p>\n                    Voltage-gated Na\n                    <jats:sup>+<\/jats:sup>\n                    channel (VGSC) \u03b21 subunits, encoded by\n                    <jats:italic>SCN1B<\/jats:italic>\n                    , are multifunctional channel modulators and cell adhesion molecules (CAMs). Mutations in\n                    <jats:italic>SCN1B<\/jats:italic>\n                    are associated with the genetic epilepsy with febrile seizures plus (GEFS+) spectrum disorders in humans, and\n                    <jats:italic>Scn1b<\/jats:italic>\n                    -null mice display severe spontaneous seizures and ataxia from postnatal day (P)10. The goal of this study was to determine changes in neuronal pathfinding during early postnatal brain development of\n                    <jats:italic>Scn1b<\/jats:italic>\n                    -null mice to test the hypothesis that these CAM-mediated roles of\n                    <jats:italic>Scn1b<\/jats:italic>\n                    may contribute to the development of hyperexcitability. c-Fos, a protein induced in response to seizure activity, was up-regulated in the\n                    <jats:italic>Scn1b<\/jats:italic>\n                    -null brain at P16 but not at P5. Consistent with this, epileptiform activity was observed in hippocampal and cortical slices prepared from the P16 but not from the P5\u2013P7\n                    <jats:italic>Scn1b<\/jats:italic>\n                    -null brain. On the basis of these results, we investigated neuronal pathfinding at P5. We observed disrupted fasciculation of parallel fibers in the P5 null cerebellum. Further, P5 null mice showed reduced neuron density in the dentate gyrus granule cell layer, increased proliferation of granule cell precursors in the hilus, and defective axonal extension and misorientation of somata and processes of inhibitory neurons in the dentate gyrus and CA1. Thus,\n                    <jats:italic>Scn1b<\/jats:italic>\n                    is critical for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brain development. We propose that defective neuronal proliferation, migration, and pathfinding in response to\n                    <jats:italic>Scn1b<\/jats:italic>\n                    deletion may contribute to the development of hyperexcitability.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1208767110","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T22:18:40Z","timestamp":1356992320000},"page":"1089-1094","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":74,"title":["Abnormal neuronal patterning occurs during early postnatal brain development of\n                    <i>Scn1b<\/i>\n                    -null mice and precedes hyperexcitability"],"prefix":"10.1073","volume":"110","author":[{"given":"William J.","family":"Brackenbury","sequence":"first","affiliation":[{"name":"Departments of aPharmacology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Parent","sequence":"additional","affiliation":[{"name":"Neurology, University of Michigan Medical School, Ann Arbor, MI 48109; and"},{"name":"Ann Arbor Veterans Administration Healthcare System, Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L.","family":"Isom","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2012,12,31]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81133-2"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00053"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858408320293"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0361-11.2011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl272"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.06.050"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-24-10699.2002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42219"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2475-09.2009"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2034-04.2004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4139-03.2004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5446-07.2008"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909434107"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4329-08.2008"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858408317008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037702"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(96)00021-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(98)00063-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2003"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.1.143"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-16-06095.2000"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5655-09.2010"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10005"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10122"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1754"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5270-06.2007"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00652-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01214-6"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1100"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.022"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90575-0"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","unstructured":"B Leuner E Gould Structural plasticity and hippocampal function. 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Current Protocols in Toxicology (Wiley, New York), pp. 11.11.11\u201311.11.38 (2003)."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1208767110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T20:42:38Z","timestamp":1649796158000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1208767110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,31]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,1,15]]}},"alternative-id":["10.1073\/pnas.1208767110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1208767110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,31]]},"assertion":[{"value":"2012-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}