{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:53:39Z","timestamp":1781106819254,"version":"3.54.1"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"34","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2012,8,21]]},"abstract":"<jats:p>\n                    Prion diseases are fatal neurodegenerative disorders that include bovine spongiform encephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by long incubation periods, variation in which is determined by many factors including genetic background. In some cases it is possible that incubation time may be directly correlated to the level of gene expression. To test this hypothesis, we combined incubation time data from five different inbred lines of mice with quantitative gene expression profiling in normal brains and identified five genes with expression levels that correlate with incubation time. One of these genes,\n                    <jats:italic>Hspa13<\/jats:italic>\n                    (\n                    <jats:italic>Stch<\/jats:italic>\n                    ), is a member of the Hsp70 family of ATPase heat shock proteins, which have been previously implicated in prion propagation. To test whether\n                    <jats:italic>Hspa13<\/jats:italic>\n                    plays a causal role in determining the incubation period, we tested two overexpressing mouse models. The Tc1 human chromosome 21 (\n                    <jats:italic>Hsa21<\/jats:italic>\n                    ) transchromosomic mouse model of Down syndrome is trisomic for many\n                    <jats:italic>Hsa21<\/jats:italic>\n                    genes including\n                    <jats:italic>Hspa13<\/jats:italic>\n                    and following Chandler\/Rocky Mountain Laboratory (RML) prion inoculation, shows a 4% reduction in incubation time. Furthermore, a transgenic model with eightfold overexpression of mouse\n                    <jats:italic>Hspa13<\/jats:italic>\n                    exhibited highly significant reductions in incubation time of 16, 15, and 7% following infection with Chandler\/RML, ME7, and MRC2 prion strains, respectively. These data further implicate Hsp70-like molecular chaperones in protein misfolding disorders such as prion disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1208917109","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T22:50:06Z","timestamp":1344293406000},"page":"13722-13727","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":22,"title":["Overexpression of the\n                    <i>Hspa13<\/i>\n                    (\n                    <i>Stch<\/i>\n                    ) gene reduces prion disease incubation time in mice"],"prefix":"10.1073","volume":"109","author":[{"given":"Julia","family":"Grizenkova","sequence":"first","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaheen","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Hummerich","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel A.","family":"Asante","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wenborn","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Fizet","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Poulter","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances K.","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M. C.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L. J.","family":"Tybulewicz","sequence":"additional","affiliation":[{"name":"Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Collinge","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Prion Unit and"},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2012,8,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.neuro.24.1.519","article-title":"Prion diseases of humans and animals: Their causes and molecular basis","volume":"24","author":"Collinge J","year":"2001","unstructured":"J Collinge, Prion diseases of humans and animals: Their causes and molecular basis. 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Mol Cell Biol 8, 5528\u20135540 (1988).","journal-title":"Mol Cell Biol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/genetics\/133.4.979","article-title":"Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse","volume":"133","author":"Carlson GA","year":"1993","unstructured":"GA Carlson, C Ebeling, M Torchia, D Westaway, SB Prusiner, Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse. Genetics 133, 979\u2013988 (1993).","journal-title":"Genetics"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00335-004-3041-5","article-title":"Identification and characterization of a novel mouse prion gene allele","volume":"15","author":"Lloyd SE","year":"2004","unstructured":"SE Lloyd, et al., Identification and characterization of a novel mouse prion gene allele. 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Protein Pept Lett 16, 571\u2013581 (2009).","journal-title":"Protein Pept Lett"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1389202053202166","article-title":"Genetic susceptibility to prion diseases in humans and mice","volume":"6","author":"Lloyd S","year":"2005","unstructured":"S Lloyd, J Collinge, Genetic susceptibility to prion diseases in humans and mice. Curr Genomics 6, 1\u201311 (2005).","journal-title":"Curr Genomics"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1126\/science.1114535","article-title":"An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes","volume":"309","author":"O\u2019Doherty A","year":"2005","unstructured":"A O\u2019Doherty, et al., An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. 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Brain 129, 1557\u20131569 (2006).","journal-title":"Brain"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"11666","DOI":"10.1073\/pnas.1834432100","article-title":"A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions","volume":"100","author":"Kl\u00f6hn PC","year":"2003","unstructured":"PC Kl\u00f6hn, L Stoltze, E Flechsig, M Enari, C Weissmann, A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. 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Nature 438, 662\u2013666 (2005).","journal-title":"Nature"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/msb.2009.10","article-title":"A systems approach to prion disease","volume":"5","author":"Hwang D","year":"2009","unstructured":"D Hwang, et al., A systems approach to prion disease. Mol Syst Biol 5, 252 (2009).","journal-title":"Mol Syst Biol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1099\/vir.0.2008\/001255-0","article-title":"Genes contributing to prion pathogenesis","volume":"89","author":"Tamg\u00fcney G","year":"2008","unstructured":"G Tamg\u00fcney, et al., Genes contributing to prion pathogenesis. J Gen Virol 89, 1777\u20131788 (2008).","journal-title":"J Gen Virol"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.06.025","article-title":"Altered regulation of tau phosphorylation in a mouse model of Down syndrome aging","author":"Sheppard O","year":"2012","unstructured":"O Sheppard, et al., Altered regulation of tau phosphorylation in a mouse model of Down syndrome aging. Neurobiol Aging, 33:828e31\u2013828e44. (2012).","journal-title":"Neurobiol Aging"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ana.410290117","article-title":"Acceleration of scrapie in trisomy 16----diploid aggregation chimeras","volume":"29","author":"Epstein CJ","year":"1991","unstructured":"CJ Epstein, DB Foster, SJ DeArmond, SB Prusiner, Acceleration of scrapie in trisomy 16----diploid aggregation chimeras. Ann Neurol 29, 95\u201397 (1991).","journal-title":"Ann Neurol"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0378-1119(97)00383-1","article-title":"A \u2018core ATPase\u2019, Hsp70-like structure is conserved in human, rat, and C. elegans STCH proteins","volume":"199","author":"Otterson GA","year":"1997","unstructured":"GA Otterson, FJ Kaye, A \u2018core ATPase\u2019, Hsp70-like structure is conserved in human, rat, and C. elegans STCH proteins. Gene 199, 287\u2013292 (1997).","journal-title":"Gene"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/156652406775574578","article-title":"Stressing out the ER: A role of the unfolded protein response in prion-related disorders","volume":"6","author":"Hetz CA","year":"2006","unstructured":"CA Hetz, C Soto, Stressing out the ER: A role of the unfolded protein response in prion-related disorders. Curr Mol Med 6, 37\u201343 (2006).","journal-title":"Curr Mol Med"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1111\/j.1582-4934.2011.01374.x","article-title":"Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders","volume":"15","author":"Doyle KM","year":"2011","unstructured":"KM Doyle, et al., Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J Cell Mol Med 15, 2025\u20132039 (2011).","journal-title":"J Cell Mol Med"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.nbd.2006.05.011","article-title":"An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity","volume":"23","author":"Ferreiro E","year":"2006","unstructured":"E Ferreiro, R Resende, R Costa, CR Oliveira, CM Pereira, An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurobiol Dis 23, 669\u2013678 (2006).","journal-title":"Neurobiol Dis"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1111\/j.1471-4159.2006.04011.x","article-title":"Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons","volume":"98","author":"Fuhrmann M","year":"2006","unstructured":"M Fuhrmann, et al., Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons. J Neurochem 98, 1876\u20131885 (2006).","journal-title":"J Neurochem"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bbrc.2008.09.013","article-title":"Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis","volume":"376","author":"Yamagata N","year":"2008","unstructured":"N Yamagata, K Furuno, M Sonoda, H Sugimura, K Yamamoto, Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis. 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(2004).","journal-title":"Stat Appl Genet Mol Biol"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0092-8674(89)90608-9","article-title":"Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques","volume":"59","author":"Scott M","year":"1989","unstructured":"M Scott, et al., Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. 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EMBO J 21, 6358\u20136366 (2002).","journal-title":"EMBO J"},{"key":"e_1_3_4_41_2","volume-title":"Manipulating the Mouse Embryo: A Laboratory Manual","author":"Hogan B","year":"1994","unstructured":"B Hogan, R Beddington, F Costantini, E Lacy Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Press, Cold Spring Harbor, NY, 1994)."},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1534\/genetics.108.090894","article-title":"Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse","volume":"180","author":"O\u2019Shea M","year":"2008","unstructured":"M O\u2019Shea, et al., Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse. 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