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In this case, we show that the molecular circadian clock, found in ovarian steroidogenic cells, is crucial for normal female reproduction, specifically embryonic implantation. The observation that implantation can be rescued by a single ovary with normal molecular clock machinery [i.e., brain muscle arnt-like 1 (BMAL1)] may provide direction for clinical intervention strategies when aberrant circadian oscillations are influencing fertility.<\/jats:p>","DOI":"10.1073\/pnas.1209249111","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T04:31:40Z","timestamp":1410841900000},"page":"14295-14300","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":119,"title":["Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice"],"prefix":"10.1073","volume":"111","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Johnson","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Shen","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Wallisser","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy J.","family":"Krentz","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Moran","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Sullivan","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"},{"name":"Research Animal Resources Center, University of Wisconsin\u2013Madison, Madison, WI 53706; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Glover","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert F.","family":"Parlow","sequence":"additional","affiliation":[{"name":"National Hormone and Peptide Program, Harbor\u2013University of California Los Angeles Medical Center, Torrance, CA 90502"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman R.","family":"Drinkwater","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Schuler","sequence":"additional","affiliation":[{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"},{"name":"Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Bradfield","sequence":"additional","affiliation":[{"name":"McArdle Laboratory for Cancer Research, and"},{"name":"Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison WI 53706;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1002\/ijc.27551","article-title":"Cancer incidence among Nordic airline cabin crew","volume":"131","author":"Pukkala E","year":"2012","unstructured":"E Pukkala, et al., Cancer incidence among Nordic airline cabin crew. 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