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Boundary formation and maintenance are poorly understood processes, despite the identification of a number of boundary-specific transcription factors. Here we provide genetic and biochemical evidence that the\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    transcription factor LATERAL ORGAN BOUNDARIES (LOB) negatively regulates accumulation of the plant steroid hormone brassinosteroid (BR) in organ boundaries. We found that ectopic expression of\n                    <jats:italic>LOB<\/jats:italic>\n                    results in reduced BR responses. We identified\n                    <jats:italic>BAS1<\/jats:italic>\n                    , which encodes a BR-inactivating enzyme, as a direct target of LOB transcriptional activation. Loss-of-function\n                    <jats:italic>lob<\/jats:italic>\n                    mutants exhibit organ fusions, and this phenotype is suppressed by expression of\n                    <jats:italic>BAS1<\/jats:italic>\n                    under the\n                    <jats:italic>LOB<\/jats:italic>\n                    promoter, indicating that BR hyperaccumulation contributes to the\n                    <jats:italic>lob<\/jats:italic>\n                    mutant phenotype. In addition,\n                    <jats:italic>LOB<\/jats:italic>\n                    expression is BR regulated; therefore, LOB and BR form a feedback loop to modulate local BR accumulation in organ boundaries to limit growth in the boundary domain.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1210789109","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T09:19:33Z","timestamp":1354699173000},"page":"21146-21151","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":187,"title":["<i>Arabidopsis<\/i>\n                    LATERAL ORGAN BOUNDARIES negatively regulates brassinosteroid accumulation to limit growth in organ boundaries"],"prefix":"10.1073","volume":"109","author":[{"given":"Elizabeth M.","family":"Bell","sequence":"first","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman Y.","family":"Husbands","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkateswari","family":"Jaganatha","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Jablonska","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Mangeon","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Neff","sequence":"additional","affiliation":[{"name":"Department of Crop and Soil Sciences, Washington State University, Pullman, WA 99164"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Girke","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia S.","family":"Springer","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Sciences, Center for Plant Cell Biology, University of California, Riverside, CA 92521; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ydbio.2009.11.029","article-title":"Twenty years on: The inner workings of the shoot apical meristem, a developmental dynamo","volume":"341","author":"Barton MK","year":"2010","unstructured":"MK Barton, Twenty years on: The inner workings of the shoot apical meristem, a developmental dynamo. Dev Biol 341, 95\u2013113 (2010).","journal-title":"Dev Biol"},{"key":"e_1_3_4_2_2","first-page":"702","article-title":"Cell division and expansion and resultant tissue tensions in shoot apex during formation of a leaf primordium in tomato","volume":"22","author":"Hussey G","year":"1971","unstructured":"G Hussey, Cell division and expansion and resultant tissue tensions in shoot apex during formation of a leaf primordium in tomato. J Exp Bot 22, 702\u2013714 (1971).","journal-title":"J Exp Bot"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1365-313X.2004.02026.x","article-title":"High-resolution boundary analysis during Arabidopsis thaliana flower development","volume":"38","author":"Breuil-Broyer S","year":"2004","unstructured":"S Breuil-Broyer, et al., High-resolution boundary analysis during Arabidopsis thaliana flower development. 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