{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:50:03Z","timestamp":1793015403869,"version":"4.5.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,1,2]]},"abstract":"<jats:p>\n                    The recent emergence of artemisinin-resistant\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    malaria in western Cambodia could threaten prospects for malaria elimination. Identification of the genetic basis of resistance would provide tools for molecular surveillance, aiding efforts to contain resistance. Clinical trials of artesunate efficacy were conducted in Bangladesh, in northwestern Thailand near the Myanmar border, and at two sites in western Cambodia. Parasites collected from trial participants were genotyped at 8,079 single nucleotide polymorphisms (SNPs) using a\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    -specific SNP array. Parasite genotypes were examined for signatures of recent positive selection and association with parasite clearance phenotypes to identify regions of the genome associated with artemisinin resistance. Four SNPs on chromosomes 10 (one), 13 (two), and 14 (one) were significantly associated with delayed parasite clearance. The two SNPs on chromosome 13 are in a region of the genome that appears to be under strong recent positive selection in Cambodia. The SNPs on chromosomes 10 and 13 lie in or near genes involved in postreplication repair, a DNA damage-tolerance pathway. Replication and validation studies are needed to refine the location of loci responsible for artemisinin resistance and to understand the mechanism behind it; however, two SNPs on chromosomes 10 and 13 may be useful markers of delayed parasite clearance in surveillance for artemisinin resistance in Southeast Asia.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1211205110","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T00:24:36Z","timestamp":1355790276000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":253,"title":["Genetic loci associated with delayed clearance of\n                    <i>Plasmodium falciparum<\/i>\n                    following artemisinin treatment in Southeast Asia"],"prefix":"10.1073","volume":"110","author":[{"given":"Shannon","family":"Takala-Harrison","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute\/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taane G.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pathogen Molecular Biology, London School of Tropical Medicine, London WC1E 7HT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute\/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivo","family":"Miotto","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, United Kingdom;"},{"name":"Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400 Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen M.","family":"Dondorp","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400 Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, 10400 Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Nosten","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400 Thailand;"},{"name":"Shoklo Malaria Research Unit, Mae Sod, Tak 63110, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Noedl","sequence":"additional","affiliation":[{"name":"Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, A-1090 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Imwong","sequence":"additional","affiliation":[{"name":"Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Bethell","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, 10400 Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youry","family":"Se","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Phnom Penh 12252, Cambodia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanthap","family":"Lon","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Phnom Penh 12252, Cambodia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart D.","family":"Tyner","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, 10400 Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Armed Forces Research Institute of Medical Sciences, Bangkok, 10400 Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong","family":"Socheat","sequence":"additional","affiliation":[{"name":"University of Health Science, Phnom Penh 12201, Cambodia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Ariey","sequence":"additional","affiliation":[{"name":"Institut Pasteur Unit\u00e9 d\u2019Immunologie Mol\u00e9culaire des Parasites, F-75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung Pyae","family":"Phyo","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400 Thailand;"},{"name":"Shoklo Malaria Research Unit, Mae Sod, Tak 63110, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Starzengruber","sequence":"additional","affiliation":[{"name":"Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, A-1090 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Fuehrer","sequence":"additional","affiliation":[{"name":"Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, A-1090 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Swoboda","sequence":"additional","affiliation":[{"name":"Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, A-1090 Vienna, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasia","family":"Stepniewska","sequence":"additional","affiliation":[{"name":"WorldWide Antimalarial Resistance Network, Oxford University, Oxford OX3 7LJ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Flegg","sequence":"additional","affiliation":[{"name":"WorldWide Antimalarial Resistance Network, Oxford University, Oxford OX3 7LJ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Arze","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo C.","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy M.","family":"Ricklefs","sequence":"additional","affiliation":[{"name":"Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Porcella","sequence":"additional","affiliation":[{"name":"Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Advanced Biomedical Computing Center, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Adams","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute\/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo J.","family":"Kenefic","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute\/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Campino","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, United Kingdom;"},{"name":"Malaria Programme, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Auburn","sequence":"additional","affiliation":[{"name":"Malaria Programme, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn","family":"MacInnis","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, United Kingdom;"},{"name":"Malaria Programme, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic P.","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, United Kingdom;"},{"name":"Malaria Programme, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-zhuan","family":"Su","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400 Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Ringwald","sequence":"additional","affiliation":[{"name":"Drug Resistance and Containment Unit, Global Malaria Programme, World Health Organization, 1211 Geneva 27, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher V.","family":"Plowe","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute\/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"; World Health Organization World Malaria Report 2011 (WHO Geneva). (2011)."},{"key":"e_1_3_4_2_2","unstructured":"; World Health Organization Antimalarial Drug Combination Therapy. Report of a WHO Technical Consultation (WHO Geneva). (2001)."},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1056\/NEJMp1108322","article-title":"The threat of artemisinin-resistant malaria","volume":"365","author":"Dondorp AM","year":"2011","unstructured":"AM Dondorp, et al., The threat of artemisinin-resistant malaria. N Engl J Med 365, 1073\u20131075 (2011).","journal-title":"N Engl J Med"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4269\/ajtmh.2007.76.641","article-title":"Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border","volume":"76","author":"Alker AP","year":"2007","unstructured":"AP Alker, et al., Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border. Am J Trop Med Hyg 76, 641\u2013647 (2007).","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/j.1365-3156.2006.01690.x","article-title":"Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia","volume":"11","author":"Denis MB","year":"2006","unstructured":"MB Denis, et al., Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia. Trop Med Int Health 11, 1360\u20131366 (2006).","journal-title":"Trop Med Int Health"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"e19283","DOI":"10.1371\/journal.pone.0019283","article-title":"Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: A randomized clinical trial","volume":"6","author":"Bethell D","year":"2011","unstructured":"D Bethell, et al., Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: A randomized clinical trial. PLoS ONE 6, e19283 (2011).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp AM","year":"2009","unstructured":"AM Dondorp, et al., Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 361, 455\u2013467 (2009).","journal-title":"N Engl J Med"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1056\/NEJMc0805011","article-title":"Evidence of artemisinin-resistant malaria in western Cambodia","volume":"359","author":"Noedl H","year":"2008","unstructured":"H Noedl, et al., Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med; Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium 359, 2619\u20132620 (2008).","journal-title":"N Engl J Med"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.trstmh.2008.11.002","article-title":"The evolution of drug-resistant malaria","volume":"103","author":"Plowe CV","year":"2009","unstructured":"CV Plowe, The evolution of drug-resistant malaria. Trans R Soc Trop Med Hyg 103, S11\u2013S14 (2009).","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/1475-2875-10-339","article-title":"Standardizing the measurement of parasite clearance in falciparum malaria: The parasite clearance estimator","volume":"10","author":"Flegg JA","year":"2011","unstructured":"JA Flegg, PJ Guerin, NJ White, K Stepniewska, Standardizing the measurement of parasite clearance in falciparum malaria: The parasite clearance estimator. Malar J 10, 339 (2011).","journal-title":"Malar J"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1086\/651562","article-title":"High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia","volume":"201","author":"Anderson TJ","year":"2010","unstructured":"TJ Anderson, et al., High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia. J Infect Dis 201, 1326\u20131330 (2010).","journal-title":"J Infect Dis"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1534\/genetics.107.080101","article-title":"Efficient control of population structure in model organism association mapping","volume":"178","author":"Kang HM","year":"2008","unstructured":"HM Kang, et al., Efficient control of population structure in model organism association mapping. Genetics 178, 1709\u20131723 (2008).","journal-title":"Genetics"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nature06250","article-title":"Genome-wide detection and characterization of positive selection in human populations","volume":"449","author":"Sabeti PC","year":"2007","unstructured":"PC Sabeti, et al., Genome-wide detection and characterization of positive selection in human populations. Nature; International HapMap Consortium 449, 913\u2013918 (2007).","journal-title":"Nature"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/genetics\/74.1.175","article-title":"Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms","volume":"74","author":"Lewontin RC","year":"1973","unstructured":"RC Lewontin, J Krakauer, Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms. Genetics 74, 175\u2013195 (1973).","journal-title":"Genetics"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: Analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett JC","year":"2005","unstructured":"JC Barrett, B Fry, J Maller, MJ Daly, Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263\u2013265 (2005).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/ng.528","article-title":"Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs","volume":"42","author":"Mu J","year":"2010","unstructured":"J Mu, et al., Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nat Genet 42, 268\u2013271 (2010).","journal-title":"Nat Genet"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1126\/science.1205216","article-title":"Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets","volume":"333","author":"Yuan J","year":"2011","unstructured":"J Yuan, et al., Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science 333, 724\u2013729 (2011).","journal-title":"Science"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nature11174","article-title":"Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing","volume":"487","author":"Manske M","year":"2012","unstructured":"M Manske, et al., Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature 487, 375\u2013379 (2012).","journal-title":"Nature"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"e1001383","DOI":"10.1371\/journal.pgen.1001383","article-title":"Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum","volume":"7","author":"Van Tyne D","year":"2011","unstructured":"D Van Tyne, et al., Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet 7, e1001383 (2011).","journal-title":"PLoS Genet"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.1215966","article-title":"A major genome region underlying artemisinin resistance in malaria","volume":"336","author":"Cheeseman IH","year":"2012","unstructured":"IH Cheeseman, et al., A major genome region underlying artemisinin resistance in malaria. Science 336, 79\u201382 (2012).","journal-title":"Science"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.pt.2006.04.008","article-title":"Progress in in silico functional genomics: The malaria Metabolic Pathways database","volume":"22","author":"Ginsburg H","year":"2006","unstructured":"H Ginsburg, Progress in in silico functional genomics: The malaria Metabolic Pathways database. Trends Parasitol 22, 238\u2013240 (2006).","journal-title":"Trends Parasitol"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2958.2007.05753.x","article-title":"Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites","volume":"65","author":"Hunt P","year":"2007","unstructured":"P Hunt, et al., Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol Microbiol 65, 27\u201340 (2007).","journal-title":"Mol Microbiol"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1073\/pnas.1104063108","article-title":"Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion","volume":"108","author":"Klonis N","year":"2011","unstructured":"N Klonis, et al., Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci USA 108, 11405\u201311410 (2011).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature07580","article-title":"RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light","volume":"457","author":"Hishida T","year":"2009","unstructured":"T Hishida, Y Kubota, AM Carr, H Iwasaki, RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light. Nature 457, 612\u2013615 (2009).","journal-title":"Nature"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1471-2164-12-391","article-title":"Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription","volume":"12","author":"Mok S","year":"2011","unstructured":"S Mok, et al., Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics 12, 391 (2011).","journal-title":"BMC Genomics"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.4161\/cc.6.13.4455","article-title":"Cdt1 interactions in the licensing process: A model for dynamic spatiotemporal control of licensing","volume":"6","author":"Xouri G","year":"2007","unstructured":"G Xouri, M Dimaki, PI Bastiaens, Z Lygerou, Cdt1 interactions in the licensing process: A model for dynamic spatiotemporal control of licensing. Cell Cycle 6, 1549\u20131552 (2007).","journal-title":"Cell Cycle"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1093\/bioinformatics\/btm443","article-title":"A genotype calling algorithm for the Illumina BeadArray platform","volume":"23","author":"Teo YY","year":"2007","unstructured":"YY Teo, et al., A genotype calling algorithm for the Illumina BeadArray platform. Bioinformatics 23, 2741\u20132746 (2007).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price AL","year":"2006","unstructured":"AL Price, et al., Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38, 904\u2013909 (2006).","journal-title":"Nat Genet"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/ng.388","article-title":"Genome-wide and fine-resolution association analysis of malaria in West Africa","volume":"41","author":"Jallow M","year":"2009","unstructured":"M Jallow, et al., Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network 41, 657\u2013665 (2009).","journal-title":"Nat Genet"},{"key":"e_1_3_4_30_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2008","unstructured":"; R Development Core Team R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, Vienna, 2008)."},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman L","year":"2001","unstructured":"L Breiman, Random forests. Mach Learn 45, 5\u201332 (2001).","journal-title":"Mach Learn"},{"key":"e_1_3_4_32_2","first-page":"18","article-title":"Classification and regression by randomForest","volume":"2","author":"Liaw A","year":"2002","unstructured":"A Liaw, M Wiener, Classification and regression by randomForest. R News 2, 18\u201322 (2002).","journal-title":"R News"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001712","article-title":"Identifying selected regions from heterozygosity and divergence using a light-coverage genomic dataset from two human populations","volume":"3","author":"Oleksyk TK","year":"2008","unstructured":"TK Oleksyk, et al., Identifying selected regions from heterozygosity and divergence using a light-coverage genomic dataset from two human populations. PLoS ONE 3, e1712. (2008).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1101\/gr.4398405","article-title":"Measures of human population structure show heterogeneity among genomic regions","volume":"15","author":"Weir BS","year":"2005","unstructured":"BS Weir, LR Cardon, AD Anderson, DM Nielsen, WG Hill, Measures of human population structure show heterogeneity among genomic regions. Genome Res 15, 1468\u20131476 (2005).","journal-title":"Genome Res"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1211205110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:43:58Z","timestamp":1654580638000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1211205110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,17]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,2]]}},"alternative-id":["10.1073\/pnas.1211205110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1211205110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,17]]},"assertion":[{"value":"2012-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}