{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:51:43Z","timestamp":1791147103840,"version":"4.1.0"},"reference-count":26,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,6,19]]},"abstract":"<jats:p>\n                    Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes, including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. &amp; Shenk, T. (1998)\n                    <jats:italic>Proc. Natl. Acad. Sci. USA<\/jats:italic>\n                    95, 14470\u201314475]. By using high-density cDNA microarrays, we show that the HCMV-regulated gene expression profile in fibroblasts does not differ substantially from the response generated by IFN. Furthermore, we identified the specific viral component triggering this response as the envelope glycoprotein B (gB). Cells treated with gB, but not other herpesviral glycoproteins, exhibited the same transcriptional profile as HCMV-infected cells. Thus, the interaction of gB with its as yet unidentified cellular receptor is the principal mechanism by which HCMV alters cellular gene expression early during infection. These findings highlight a pioneering paradigm for the consequences of virus\u2013receptor interactions.\n                  <\/jats:p>","DOI":"10.1073\/pnas.121177598","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:45:09Z","timestamp":1027680309000},"page":"7140-7145","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":173,"title":["Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B"],"prefix":"10.1073","volume":"98","author":[{"given":"Kenneth A.","family":"Simmen","sequence":"first","affiliation":[{"name":"The R. W. Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121; McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706; Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasbir","family":"Singh","sequence":"additional","affiliation":[{"name":"The R. W. Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121; McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706; Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. G. Mattias","family":"Luukkonen","sequence":"additional","affiliation":[{"name":"The R. W. 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