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To uncover its in vivo functions in the retina, we generated a knockout mouse model, designated \u201c\n                    <jats:italic>miR-183C<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>GT\/GT<\/jats:italic>\n                    <\/jats:sup>\n                    ,\u201d using a gene-trap embryonic stem cell clone. We provide evidence that inactivation of the cluster results in early-onset and progressive synaptic defects of the photoreceptors, leading to abnormalities of scotopic and photopic electroretinograms with decreased\n                    <jats:italic>b<\/jats:italic>\n                    -wave amplitude as the primary defect and progressive retinal degeneration. In addition, inactivation of the\n                    <jats:italic>miR-183\/96\/182<\/jats:italic>\n                    cluster resulted in global changes in retinal gene expression, with enrichment of genes important for synaptogenesis, synaptic transmission, photoreceptor morphogenesis, and phototransduction, suggesting that the\n                    <jats:italic>miR-183\/96\/182<\/jats:italic>\n                    cluster plays important roles in postnatal functional differentiation and synaptic connectivity of photoreceptors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1212655110","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T02:27:25Z","timestamp":1358908045000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":165,"title":["Inactivation of the microRNA\n                    <i>-183\/96\/182<\/i>\n                    cluster results in syndromic retinal degeneration"],"prefix":"10.1073","volume":"110","author":[{"given":"Stephen","family":"Lumayag","sequence":"first","affiliation":[{"name":"Departments of aPharmacology,"},{"name":"Ophthalmology, and"},{"name":"Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Haldin","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"},{"name":"Ophthalmology, and"},{"name":"Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J.","family":"Corbett","sequence":"additional","affiliation":[{"name":"Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Wahlin","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Cowan","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"},{"name":"Ophthalmology, and"},{"name":"Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Turturro","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"},{"name":"Ophthalmology, and"},{"name":"Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Biosciences Division, Argonne National Laboratory, Lemont, IL 60439; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"},{"name":"Ophthalmology, and"},{"name":"Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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