{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:05:29Z","timestamp":1791295529704,"version":"4.1.0"},"reference-count":54,"publisher":"National Academy of Sciences","issue":"41","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2012,10,9]]},"abstract":"<jats:p>\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    is a foodborne pathogen that crosses the intestinal barrier and disseminates within the host. Here, we report a unique comprehensive analysis of the impact of two\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    species,\n                    <jats:italic>Lactobacillus paracasei<\/jats:italic>\n                    CNCM I-3689 and\n                    <jats:italic>Lactobacillus casei<\/jats:italic>\n                    BL23, on\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    and orally acquired listeriosis in a gnotobiotic humanized mouse model. We first assessed the effect of treatment with each\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    on\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    counts in host tissues and showed that each decreases\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    systemic dissemination in orally inoculated mice. A whole genome intestinal transcriptomic analysis revealed that each\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    changes expression of a specific subset of genes during infection, with IFN-stimulated genes (ISGs) being the most affected by both lactobacilli. We also examined microRNA (miR) expression and showed that three miRs (miR-192, miR-200b, and miR-215) are repressed during\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    infection. Treatment with each\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    increased miR-192 expression, whereas only\n                    <jats:italic>L. casei<\/jats:italic>\n                    association increased miR-200b and miR-215 expression. Finally, we showed that treatment with each\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    significantly reshaped the\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    transcriptome and up-regulated transcription of\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    genes encoding enzymes allowing utilization of intestinal carbon and nitrogen sources in particular genes involved in propanediol and ethanolamine catabolism and cobalamin biosynthesis. Altogether, these data reveal that the modulation of\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    infection by treatment with lactobacilli correlates with a decrease in host gene expression, in particular ISGs, miR regulation, and a dramatic reshaping of\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    transcriptome.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1212809109","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T06:48:49Z","timestamp":1348555729000},"page":"16684-16689","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":131,"title":["Impact of lactobacilli on orally acquired listeriosis"],"prefix":"10.1073","volume":"109","author":[{"given":"Cristel","family":"Archambaud","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 604, F-75015 Paris, France;"},{"name":"Institut National de la Recherche Agronomique, USC2020, F-75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Nahori","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 604, F-75015 Paris, France;"},{"name":"Institut National de la Recherche Agronomique, USC2020, F-75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Soubigou","sequence":"additional","affiliation":[{"name":"G\u00e9nopole, Plateforme Transcriptome and Epigenome,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"B\u00e9cavin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 604, F-75015 Paris, France;"},{"name":"Institut National de la Recherche Agronomique, USC2020, F-75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Laval","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Equipe Interactions des Bact\u00e9ries Commensales et Probiotiques avec l'H\u00f4te, Unit\u00e9 Mixte de Recherche 1319 Micalis, Jouy en Josas, France;"},{"name":"Danone Research, 91767 Palaiseau Cedex, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lechat","sequence":"additional","affiliation":[{"name":"G\u00e9nopole, Plateforme de Bioanalyse G\u00e9nomique, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Smokvina","sequence":"additional","affiliation":[{"name":"Danone Research, 91767 Palaiseau Cedex, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Langella","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Equipe Interactions des Bact\u00e9ries Commensales et Probiotiques avec l'H\u00f4te, Unit\u00e9 Mixte de Recherche 1319 Micalis, Jouy en Josas, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lecuit","sequence":"additional","affiliation":[{"name":"Groupe Microorganismes et Barri\u00e8res de l\u2019H\u00f4te, Institut Pasteur, 75015 Paris, France;"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne-Paris Cit\u00e9, Centre d'Infectiologie Necker-Pasteur, Service des Maladies Infectieuses et Tropicales, H\u00f4pital Necker-Enfants Malades, Assistance Publique-H\u00f4pitaux de Paris, F-75015 Paris, France; and"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Avenir U604, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Interactions Bact\u00e9ries-Cellules,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 604, F-75015 Paris, France;"},{"name":"Institut National de la Recherche Agronomique, USC2020, F-75015 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2009"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101958108"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.07.036"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(10)72001-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2010.536522"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112371108"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110560"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.3956"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07303"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059852"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1993.tb06339.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1046"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00264.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765X.2002.01171.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-010-0170-1"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.10.019"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.44.2.445-451.1984"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2007.02250.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700440104"},{"key":"e_1_3_3_21_2","unstructured":"; Patent Application Publication Novel strain of Lactobacillus paracasei subspecies paracasei having antimicrobial and immunomodulary properties. 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