{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:30:23Z","timestamp":1793359823609,"version":"4.5.0"},"reference-count":121,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,1,8]]},"abstract":"<jats:p>\n                    Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adaptation is of critical importance to agriculture. To test whether mechanisms to overcome plant defenses predispose the development of pesticide resistance, we examined adaptation of the generalist two-spotted spider mite,\n                    <jats:italic>Tetranychus urticae<\/jats:italic>\n                    , to host plant transfer and pesticides.\n                    <jats:italic>T. urticae<\/jats:italic>\n                    is an extreme polyphagous pest with more than 1,100 documented hosts and has an extraordinary ability to develop pesticide resistance. When mites from a pesticide-susceptible strain propagated on bean were adapted to a challenging host (tomato), transcriptional responses increased over time with \u223c7.5% of genes differentially expressed after five generations. Whereas many genes with altered expression belonged to known detoxification families (like P450 monooxygenases), new gene families not previously associated with detoxification in other herbivores showed a striking response, including ring-splitting dioxygenase genes acquired by horizontal gene transfer. Strikingly, transcriptional profiles of tomato-adapted mites resembled those of multipesticide-resistant strains, and adaptation to tomato decreased the susceptibility to unrelated pesticide classes. Our findings suggest key roles for both an expanded environmental response gene repertoire and transcriptional regulation in the life history of generalist herbivores. They also support a model whereby selection for the ability to mount a broad response to the diverse defense chemistry of plants predisposes the evolution of pesticide resistance in generalists.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1213214110","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T00:24:36Z","timestamp":1355790276000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":399,"title":["A link between host plant adaptation and pesticide resistance in the polyphagous spider mite\n                    <i>Tetranychus urticae<\/i>"],"prefix":"10.1073","volume":"110","author":[{"given":"Wannes","family":"Dermauw","sequence":"first","affiliation":[{"name":"Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Wybouw","sequence":"additional","affiliation":[{"name":"Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Rombauts","sequence":"additional","affiliation":[{"name":"Department of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, B-9052 Ghent, Belgium;"},{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Menten","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Ghent University, B-9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vontas","sequence":"additional","affiliation":[{"name":"Faculty of Applied Biology and Biotechnology, Department of Biology, University of Crete, 71409 Heraklion, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"Grbi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Western Ontario, London N6A 5B7 ON, Canada;"},{"name":"Instituto de Ciencias de la Vid y del Vino Consejo Superior de Investigaciones Cientificas, Universidad de la Rioja, 26006 Logro\u00f1o, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Utah, Salt Lake City, UT 84112;"},{"name":"Center for Cell and Genome Science, University of Utah, Salt Lake City, UT 84112; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Feyereisen","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique and Universit\u00e9 de Nice Sophia Antipolis, 06903 Sophia Antipolis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_1_2_18_9_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.51.110104.151104"},{"key":"e_1_1_2_18_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10640"},{"key":"e_1_1_2_18_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2010.05.008"},{"key":"e_1_1_2_18_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00378969"},{"key":"e_1_1_2_18_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-5347(94)90079-5"},{"key":"e_1_3_4_1_2","volume-title":"Insects on Plants: Community Patterns and Mechanisms","author":"Strong DR","year":"1984","unstructured":"DR Strong, JH Lawton, TRE Southwood Insects on Plants: Community Patterns and Mechanisms (Blackwell Scientific, Oxford, 1984)."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"18054","DOI":"10.1073\/pnas.0904106106","article-title":"Macroevolution and the biological diversity of plants and herbivores","volume":"106","author":"Futuyma DJ","year":"2009","unstructured":"DJ Futuyma, AA Agrawal, Macroevolution and the biological diversity of plants and herbivores. Proc Natl Acad Sci USA 106, 18054\u201318061 (2009).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","DOI":"10.1007\/b102508","volume-title":"Host-Plant Selection by Phytophagous Insects","author":"Bernays EA","year":"1994","unstructured":"EA Bernays, RF Chapman Host-Plant Selection by Phytophagous Insects (Chapman & Hall, New York, 1994)."},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1086\/368346","article-title":"Herbivore responses to plant secondary compounds: A test of phytochemical coevolution theory","volume":"161","author":"Cornell HV","year":"2003","unstructured":"HV Cornell, BA Hawkins, Herbivore responses to plant secondary compounds: A test of phytochemical coevolution theory. Am Nat 161, 507\u2013522 (2003).","journal-title":"Am Nat"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1086\/285907","article-title":"On defining key innovations in an adaptive radiation - cytochrome P450s and Papilionidae","volume":"148","author":"Berenbaum MR","year":"1996","unstructured":"MR Berenbaum, C Favret, MA Schuler, On defining key innovations in an adaptive radiation - cytochrome P450s and Papilionidae. Am Nat 148, S139\u2013S155 (1996).","journal-title":"Am Nat"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","DOI":"10.7208\/chicago\/9780226797670.001.0001","volume-title":"The Coevolutionary Process","author":"Thompson JN","year":"1994","unstructured":"JN Thompson The Coevolutionary Process (Univ of Chicago Press, Chicago, 1994)."},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tplants.2012.02.006","article-title":"Specialist versus generalist insect herbivores and plant defense","volume":"17","author":"Ali JG","year":"2012","unstructured":"JG Ali, AA Agrawal, Specialist versus generalist insect herbivores and plant defense. Trends Plant Sci 17, 293\u2013302 (2012).","journal-title":"Trends Plant Sci"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1126\/science.172.3983.579","article-title":"Detoxication enzymes in the guts of caterpillars: An evolutionary answer to plant defenses?","volume":"172","author":"Krieger RI","year":"1971","unstructured":"RI Krieger, PP Feeny, CF Wilkinson, Detoxication enzymes in the guts of caterpillars: An evolutionary answer to plant defenses? Science 172, 579\u2013581 (1971).","journal-title":"Science"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/bk-1992-0505.ch009","article-title":"Cytochrome-P450 monooxygenase genes in oligophagous Lepidoptera","volume":"505","author":"Berenbaum MR","year":"1992","unstructured":"MR Berenbaum, MB Cohen, MA Schuler, Cytochrome-P450 monooxygenase genes in oligophagous Lepidoptera. ACS Symp Ser 505, 114\u2013124 (1992).","journal-title":"ACS Symp Ser"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.en.06.010161.000331","article-title":"Nutritional factors in insect resistance to chemicals","volume":"6","author":"Gordon HT","year":"1961","unstructured":"HT Gordon, Nutritional factors in insect resistance to chemicals. Annu Rev Entomol 6, 27\u201354 (1961).","journal-title":"Annu Rev Entomol"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/978-1-4684-4466-7_29","volume-title":"Pest Resistance to Pesticides","author":"Croft BA","year":"1983","unstructured":"BA Croft, K Strickler Pest Resistance to Pesticides, eds GP Georghiou, T Saito (Plenum, New York), pp. 669\u2013702 (1983)."},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jee\/89.2.263","article-title":"Biochemical preadaptations, founder events, and the evolution of resistance in arthropods","volume":"89","author":"Rosenheim JA","year":"1996","unstructured":"JA Rosenheim, MW Johnson, RFL Mau, SC Welter, BE Tabashnik, Biochemical preadaptations, founder events, and the evolution of resistance in arthropods. J Econ Entomol 89, 263\u2013273 (1996).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01020571","article-title":"Enzymatic adaptations of herbivorous insects and mites to phytochemicals","volume":"12","author":"Ahmad S","year":"1986","unstructured":"S Ahmad, Enzymatic adaptations of herbivorous insects and mites to phytochemicals. J Chem Ecol 12, 533\u2013560 (1986).","journal-title":"J Chem Ecol"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/jee\/73.6.771","article-title":"Influence of host plants on insecticide metabolism and management of variegated cutworm (Lepidoptera, Noctuidae)","volume":"73","author":"Berry RE","year":"1980","unstructured":"RE Berry, SJ Yu, LC Terriere, Influence of host plants on insecticide metabolism and management of variegated cutworm (Lepidoptera, Noctuidae). J Econ Entomol 73, 771\u2013774 (1980).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.196.4296.1349","article-title":"Herbivore-plant interactions: Mixed-function oxidases and secondary plant substances","volume":"196","author":"Brattsten LB","year":"1977","unstructured":"LB Brattsten, CF Wilkinson, T Eisner, Herbivore-plant interactions: Mixed-function oxidases and secondary plant substances. Science 196, 1349\u20131352 (1977).","journal-title":"Science"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S0007485308006329","article-title":"Host plant influence on susceptibility of Bemisia tabaci (Hemiptera: Aleyrodidae) to insecticides","volume":"99","author":"Castle SJ","year":"2009","unstructured":"SJ Castle, N Prabhaker, TJ Henneberry, NC Toscano, Host plant influence on susceptibility of Bemisia tabaci (Hemiptera: Aleyrodidae) to insecticides. Bull Entomol Res 99, 263\u2013273 (2009).","journal-title":"Bull Entomol Res"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1570-7458.1982.tb03132.x","article-title":"Cross-resistance to pesticides and plant defenses: A study of the two-spotted spider-mite","volume":"31","author":"Gould F","year":"1982","unstructured":"F Gould, CR Carroll, DJ Futuyma, Cross-resistance to pesticides and plant defenses: A study of the two-spotted spider-mite. Entomol Exp Appl 31, 175\u2013180 (1982).","journal-title":"Entomol Exp Appl"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1570-7458.1984.tb03396.x","article-title":"2-tridecanone, tomatoes and Heliothis zea - potential incompatibility of plant antibiosis with insecticidal control","volume":"35","author":"Kennedy GG","year":"1984","unstructured":"GG Kennedy, 2-tridecanone, tomatoes and Heliothis zea - potential incompatibility of plant antibiosis with insecticidal control. Entomol Exp Appl 35, 305\u2013311 (1984).","journal-title":"Entomol Exp Appl"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1073\/pnas.0308691101","article-title":"Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450","volume":"101","author":"Li X","year":"2004","unstructured":"X Li, J Baudry, MR Berenbaum, MA Schuler, Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450. Proc Natl Acad Sci USA 101, 2939\u20132944 (2004).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1603\/0022-0493-93.1.18","article-title":"Cross-resistance to alpha-cypermethrin after xanthotoxin ingestion in Helicoverpa zea (Lepidoptera: Noctuidae)","volume":"93","author":"Li X","year":"2000","unstructured":"X Li, AR Zangerl, MA Schuler, MR Berenbaum, Cross-resistance to alpha-cypermethrin after xanthotoxin ingestion in Helicoverpa zea (Lepidoptera: Noctuidae). J Econ Entomol 93, 18\u201325 (2000).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_21_2","first-page":"2019","article-title":"Chemical ecology of the luna moth effects of host plant on detoxification enzyme-activity","volume":"15","author":"Lindroth RL","year":"1989","unstructured":"RL Lindroth, Chemical ecology of the luna moth effects of host plant on detoxification enzyme-activity. J Chem Ecol 15, 2019\u20132029 (1989).","journal-title":"J Chem Ecol"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.gene.2004.04.028","article-title":"Molecular analysis of CYP321A1, a novel cytochrome P450 involved in metabolism of plant allelochemicals (furanocoumarins) and insecticides (cypermethrin) in Helicoverpa zea","volume":"338","author":"Sasabe M","year":"2004","unstructured":"M Sasabe, ZM Wen, MR Berenbaum, MA Schuler, Molecular analysis of CYP321A1, a novel cytochrome P450 involved in metabolism of plant allelochemicals (furanocoumarins) and insecticides (cypermethrin) in Helicoverpa zea. Gene 338, 163\u2013175 (2004).","journal-title":"Gene"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10886-006-9238-1","article-title":"Allelochemical induction of cytochrome P450 monooxygenases and amelioration of xenobiotic toxicity in Helicoverpa zea","volume":"33","author":"Zeng RS","year":"2007","unstructured":"RS Zeng, Z Wen, G Niu, MA Schuler, MR Berenbaum, Allelochemical induction of cytochrome P450 monooxygenases and amelioration of xenobiotic toxicity in Helicoverpa zea. J Chem Ecol 33, 449\u2013461 (2007).","journal-title":"J Chem Ecol"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1603\/0022-0493-94.2.381","article-title":"Host plant-induced changes in detoxification enzymes and susceptibility to pesticides in the twospotted spider mite (Acari: Tetranychidae)","volume":"94","author":"Yang XM","year":"2001","unstructured":"XM Yang, DC Margolies, KY Zhu, LL Buschman, Host plant-induced changes in detoxification enzymes and susceptibility to pesticides in the twospotted spider mite (Acari: Tetranychidae). J Econ Entomol 94, 381\u2013387 (2001).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0048-3575(79)90113-5","article-title":"Host plant stimulation of detoxifying enzymes in a phytophagous insect","volume":"12","author":"Yu SJ","year":"1979","unstructured":"SJ Yu, RE Berry, LC Terriere, Host plant stimulation of detoxifying enzymes in a phytophagous insect. Pestic Biochem Physiol 12, 280\u2013284 (1979).","journal-title":"Pestic Biochem Physiol"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/B978-0-12-384747-8.10008-X","volume-title":"Insect Molecular Biology and Biochemistry","author":"Feyereisen R","year":"2012","unstructured":"R Feyereisen Insect Molecular Biology and Biochemistry, ed LI Gilbert (Academic Press, Elsevier, London), pp. 236\u2013316 (2012)."},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.ento.51.110104.151104","article-title":"Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics","volume":"52","author":"Li X","year":"2007","unstructured":"X Li, MA Schuler, MR Berenbaum, Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics. Annu Rev Entomol 52, 231\u2013253 (2007).","journal-title":"Annu Rev Entomol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.tree.2007.02.010","article-title":"The evolutionary ecology of insect resistance to plant chemicals","volume":"22","author":"Despr\u00e9s L","year":"2007","unstructured":"L Despr\u00e9s, JP David, C Gallet, The evolutionary ecology of insect resistance to plant chemicals. Trends Ecol Evol 22, 298\u2013307 (2007).","journal-title":"Trends Ecol Evol"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature10640","article-title":"The genome of Tetranychus urticae reveals herbivorous pest adaptations","volume":"479","author":"Grbi\u0107 M","year":"2011","unstructured":"M Grbi\u0107, et al., The genome of Tetranychus urticae reveals herbivorous pest adaptations. Nature 479, 487\u2013492 (2011).","journal-title":"Nature"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1890\/0012-9658(2000)081[0500:HREAAT]2.0.CO;2","article-title":"Host-range evolution: Adaptation and trade-offs in fitness of mites on alternative hosts","volume":"81","author":"Agrawal AA","year":"2000","unstructured":"AA Agrawal, Host-range evolution: Adaptation and trade-offs in fitness of mites on alternative hosts. Ecology 81, 500\u2013508 (2000).","journal-title":"Ecology"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2148-9-182","article-title":"Are adaptation costs necessary to build up a local adaptation pattern?","volume":"9","author":"Magalh\u00e3es S","year":"2009","unstructured":"S Magalh\u00e3es, E Blanchet, M Egas, I Olivieri, Are adaptation costs necessary to build up a local adaptation pattern? BMC Evol Biol 9, 182 (2009).","journal-title":"BMC Evol Biol"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/BF00378969","article-title":"Evolutionary adaptation to host plants in a laboratory population of the phytophagous mite Tetranychus urticae Koch","volume":"81","author":"Fry JD","year":"1989","unstructured":"JD Fry, Evolutionary adaptation to host plants in a laboratory population of the phytophagous mite Tetranychus urticae Koch. Oecologia 81, 559\u2013565 (1989).","journal-title":"Oecologia"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1111\/j.1420-9101.2007.01365.x","article-title":"Adaptation in a spider mite population after long-term evolution on a single host plant","volume":"20","author":"Magalh\u00e3es S","year":"2007","unstructured":"S Magalh\u00e3es, J Fayard, A Janssen, D Carbonell, I Olivieri, Adaptation in a spider mite population after long-term evolution on a single host plant. J Evol Biol 20, 2016\u20132027 (2007).","journal-title":"J Evol Biol"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ibmb.2010.05.008","article-title":"Acaricide resistance mechanisms in the two-spotted spider mite Tetranychus urticae and other important Acari: A review","volume":"40","author":"Van Leeuwen T","year":"2010","unstructured":"T Van Leeuwen, J Vontas, A Tsagkarakou, W Dermauw, L Tirry, Acaricide resistance mechanisms in the two-spotted spider mite Tetranychus urticae and other important Acari: A review. Insect Biochem Mol Biol 40, 563\u2013572 (2010).","journal-title":"Insect Biochem Mol Biol"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1603\/0022-0493-96.6.1626","article-title":"Haplodiploidy, sex, and the evolution of pesticide resistance","volume":"96","author":"Carri\u00e8re Y","year":"2003","unstructured":"Y Carri\u00e8re, Haplodiploidy, sex, and the evolution of pesticide resistance. J Econ Entomol 96, 1626\u20131640 (2003).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1098\/rstb.1998.0328","article-title":"Challenges with managing insecticide resistance in agricultural pests, exemplified by the whitefly Bemisia tabaci","volume":"353","author":"Denholm I","year":"1998","unstructured":"I Denholm, M Cahill, TJ Dennehy, AR Horowitz, Challenges with managing insecticide resistance in agricultural pests, exemplified by the whitefly Bemisia tabaci. Philos Trans R Soc B Biol Sci 353, 1757\u20131767 (1998).","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/ps.2191","article-title":"Acaricide resistance and resistance mechanisms in Tetranychus urticae populations from rose greenhouses in the Netherlands","volume":"67","author":"Khajehali J","year":"2011","unstructured":"J Khajehali, P Van Nieuwenhuyse, P Demaeght, L Tirry, T Van Leeuwen, Acaricide resistance and resistance mechanisms in Tetranychus urticae populations from rose greenhouses in the Netherlands. Pest Manag Sci 67, 1424\u20131433 (2011).","journal-title":"Pest Manag Sci"},{"key":"e_1_3_4_38_2","article-title":"Spider mite control and resistance management: Does a genome help?","author":"Van Leeuwen T","year":"2012","unstructured":"T Van Leeuwen, W Dermauw, M Grbic, L Tirry, R Feyereisen, Spider mite control and resistance management: Does a genome help? Pest Manag Sci, 2012).","journal-title":"Pest Manag Sci"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"e26927","DOI":"10.1371\/journal.pone.0026927","article-title":"Heritability and artificial selection on ambulatory dispersal distance in Tetranychus urticae: Effects of density and maternal effects","volume":"6","author":"Bitume EV","year":"2011","unstructured":"EV Bitume, et al., Heritability and artificial selection on ambulatory dispersal distance in Tetranychus urticae: Effects of density and maternal effects. PLoS ONE 6, e26927 (2011).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_40_2","first-page":"233","volume-title":"Spider Mites. Their Biology, Natural Enemies and Control","author":"Kennedy GG","year":"1985","unstructured":"GG Kennedy, DR Smitley Spider Mites. Their Biology, Natural Enemies and Control, eds W Helle, MW Sabelis (Elsevier, Amsterdam) Vol 1A, 233\u2013242 (1985)."},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1073\/pnas.1200068109","article-title":"Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin synthesis inhibitor in arthropods","volume":"109","author":"Van Leeuwen T","year":"2012","unstructured":"T Van Leeuwen, et al., Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin synthesis inhibitor in arthropods. Proc Natl Acad Sci USA 109, 4407\u20134412 (2012).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/86730","article-title":"Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer","volume":"19","author":"Hughes TR","year":"2001","unstructured":"TR Hughes, et al., Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat Biotechnol 19, 342\u2013347 (2001).","journal-title":"Nat Biotechnol"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ps.1001","article-title":"Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae","volume":"61","author":"Van Leeuwen T","year":"2005","unstructured":"T Van Leeuwen, S Van Pottelberge, L Tirry, Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae. Pest Manag Sci 61, 499\u2013507 (2005).","journal-title":"Pest Manag Sci"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"D225","DOI":"10.1093\/nar\/gkq1189","article-title":"CDD: A Conserved Domain Database for the functional annotation of proteins","volume":"39","author":"Marchler-Bauer A","year":"2011","unstructured":"A Marchler-Bauer, et al., CDD: A Conserved Domain Database for the functional annotation of proteins. Nucleic Acids Res 39, D225\u2013D229 (2011).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/10409230600817422","article-title":"The ins and outs of ring-cleaving dioxygenases","volume":"41","author":"Vaillancourt FH","year":"2006","unstructured":"FH Vaillancourt, JT Bolin, LD Eltis, The ins and outs of ring-cleaving dioxygenases. Crit Rev Biochem Mol Biol 41, 241\u2013267 (2006).","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"21144","DOI":"10.1074\/jbc.M500666200","article-title":"Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation","volume":"280","author":"Ferraroni M","year":"2005","unstructured":"M Ferraroni, et al., Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. J Biol Chem 280, 21144\u201321154 (2005).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jsb.2009.12.023","article-title":"Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure\/activity relationship and the crystal structures of native enzyme and catechols adducts","volume":"170","author":"Matera I","year":"2010","unstructured":"I Matera, et al., Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: Quantitative structure\/activity relationship and the crystal structures of native enzyme and catechols adducts. J Struct Biol 170, 548\u2013564 (2010).","journal-title":"J Struct Biol"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0969-2126(00)00122-2","article-title":"The 1.8 A crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker","volume":"8","author":"Vetting MW","year":"2000","unstructured":"MW Vetting, DH Ohlendorf, The 1.8 A crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker. Structure 8, 429\u2013440 (2000).","journal-title":"Structure"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-2958.2007.05671.x","article-title":"Mutualism and pathogenesis in Xenorhabdus and Photorhabdus: Two roads to the same destination","volume":"64","author":"Goodrich-Blair H","year":"2007","unstructured":"H Goodrich-Blair, DJ Clarke, Mutualism and pathogenesis in Xenorhabdus and Photorhabdus: Two roads to the same destination. Mol Microbiol 64, 260\u2013268 (2007).","journal-title":"Mol Microbiol"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1002\/pmic.200700184","article-title":"Comparative proteomics of extracellular proteins in vitro and in planta from the pathogenic fungus Fusarium graminearum","volume":"7","author":"Paper JM","year":"2007","unstructured":"JM Paper, JS Scott-Craig, ND Adhikari, CA Cuomo, JD Walton, Comparative proteomics of extracellular proteins in vitro and in planta from the pathogenic fungus Fusarium graminearum. Proteomics 7, 3171\u20133183 (2007).","journal-title":"Proteomics"},{"key":"e_1_3_4_51_2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1364-3703.2011.00759.x","article-title":"Secretomics identifies Fusarium graminearum proteins involved in the interaction with barley and wheat","volume":"13","author":"Yang F","year":"2012","unstructured":"F Yang, et al., Secretomics identifies Fusarium graminearum proteins involved in the interaction with barley and wheat. Mol Plant Pathol 13, 445\u2013453 (2012).","journal-title":"Mol Plant Pathol"},{"key":"e_1_3_4_52_2","first-page":"49","volume-title":"Lipocalins","author":"Ganfornina MD","year":"2006","unstructured":"MD Ganfornina, H Kayser, D Sanchez Lipocalins, eds B \u00c5kerstr\u00f6m, N Borregaard, DR Flower, JP Salier (Landes Bioscience, Austin, TX), pp. 49\u201374 (2006)."},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbapap.2005.12.006","article-title":"Comparative ligand-binding analysis of ten human lipocalins","volume":"1764","author":"Breustedt DA","year":"2006","unstructured":"DA Breustedt, DL Sch\u00f6nfeld, A Skerra, Comparative ligand-binding analysis of ten human lipocalins. Biochim Biophys Acta 1764, 161\u2013173 (2006).","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_4_54_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2005.11.005","article-title":"An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks","volume":"36","author":"Ribeiro JMC","year":"2006","unstructured":"JMC Ribeiro, et al., An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks. Insect Biochem Mol Biol 36, 111\u2013129 (2006).","journal-title":"Insect Biochem Mol Biol"},{"key":"e_1_3_4_55_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0167-4838(00)00148-5","article-title":"The lipocalin protein family: Structural and sequence overview","volume":"1482","author":"Flower DR","year":"2000","unstructured":"DR Flower, ACT North, CE Sansom, The lipocalin protein family: Structural and sequence overview. Biochim Biophys Acta 1482, 9\u201324 (2000).","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_4_56_2","first-page":"5","volume-title":"Lipocalins","author":"Sanchez D","year":"2006","unstructured":"D Sanchez, et al. Lipocalins, eds B \u00c5kerstr\u00f6m, N Borregaard, DR Flower, JP Salier (Landes Bioscience, Austin, TX), pp. 5\u201316 (2006)."},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/oxfordjournals.molbev.a026224","article-title":"A phylogenetic analysis of the lipocalin protein family","volume":"17","author":"Ganfornina MD","year":"2000","unstructured":"MD Ganfornina, G Guti\u00e9rrez, M Bastiani, D S\u00e1nchez, A phylogenetic analysis of the lipocalin protein family. Mol Biol Evol 17, 114\u2013126 (2000).","journal-title":"Mol Biol Evol"},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/molbev\/msp092","article-title":"Evolution of a novel carotenoid-binding protein responsible for crustacean shell color","volume":"26","author":"Wade NM","year":"2009","unstructured":"NM Wade, A Tollenaere, MR Hall, BM Degnan, Evolution of a novel carotenoid-binding protein responsible for crustacean shell color. Mol Biol Evol 26, 1851\u20131864 (2009).","journal-title":"Mol Biol Evol"},{"key":"e_1_3_4_59_2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2005.06.025","article-title":"Identification of an intestinal heme transporter","volume":"122","author":"Shayeghi M","year":"2005","unstructured":"M Shayeghi, et al., Identification of an intestinal heme transporter. Cell 122, 789\u2013801 (2005).","journal-title":"Cell"},{"key":"e_1_3_4_60_2","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1101\/gad.17280911","article-title":"Transcriptional regulation of xenobiotic detoxification in Drosophila","volume":"25","author":"Misra JR","year":"2011","unstructured":"JR Misra, MA Horner, G Lam, CS Thummel, Transcriptional regulation of xenobiotic detoxification in Drosophila. Genes Dev 25, 1796\u20131806 (2011).","journal-title":"Genes Dev"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.47.120505.105349","article-title":"The tangle of nuclear receptors that controls xenobiotic metabolism and transport: Crosstalk and consequences","volume":"48","author":"Pascussi J-M","year":"2008","unstructured":"J-M Pascussi, et al., The tangle of nuclear receptors that controls xenobiotic metabolism and transport: Crosstalk and consequences. Annu Rev Pharmacol Toxicol 48, 1\u201332 (2008).","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"e_1_3_4_62_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/A:1017926017081","article-title":"Trade-offs in performance on different plants may not restrict the host plant range of the phytophagous mite, Tetranychus urticae","volume":"25","author":"Yano S","year":"2001","unstructured":"S Yano, J Takabayashi, A Takafuji, Trade-offs in performance on different plants may not restrict the host plant range of the phytophagous mite, Tetranychus urticae. Exp Appl Acarol 25, 371\u2013381 (2001).","journal-title":"Exp Appl Acarol"},{"key":"e_1_3_4_63_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1570-7458.1993.tb01700.x","article-title":"Host race formation in Tetranychus urticae - Genetic differentiation, host-plant preference, and mate choice in a tomato and a cucumber strain","volume":"68","author":"Gotoh T","year":"1993","unstructured":"T Gotoh, J Bruin, MW Sabelis, SBJ Menken, Host race formation in Tetranychus urticae - Genetic differentiation, host-plant preference, and mate choice in a tomato and a cucumber strain. Entomol Exp Appl 68, 171\u2013178 (1993).","journal-title":"Entomol Exp Appl"},{"key":"e_1_3_4_64_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1098\/rspb.2007.1277","article-title":"Intraspecific variation in a generalist herbivore accounts for differential induction and impact of host plant defences","volume":"275","author":"Kant MR","year":"2008","unstructured":"MR Kant, MW Sabelis, MA Haring, RC Schuurink, Intraspecific variation in a generalist herbivore accounts for differential induction and impact of host plant defences. Proc R Soc B Biol Sci 275, 443\u2013452 (2008).","journal-title":"Proc R Soc B Biol Sci"},{"key":"e_1_3_4_65_2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1023\/A:1015260931034","article-title":"Postgenomic chemical ecology: From genetic code to ecological interactions","volume":"28","author":"Berenbaum MR","year":"2002","unstructured":"MR Berenbaum, Postgenomic chemical ecology: From genetic code to ecological interactions. J Chem Ecol 28, 873\u2013896 (2002).","journal-title":"J Chem Ecol"},{"key":"e_1_3_4_66_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cmet.2006.06.006","article-title":"The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila","volume":"4","author":"King-Jones K","year":"2006","unstructured":"K King-Jones, MA Horner, G Lam, CS Thummel, The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. Cell Metab 4, 37\u201348 (2006).","journal-title":"Cell Metab"},{"key":"e_1_3_4_67_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.asd.2010.01.003","article-title":"Geological history and phylogeny of Chelicerata","volume":"39","author":"Dunlop JA","year":"2010","unstructured":"JA Dunlop, Geological history and phylogeny of Chelicerata. Arthropod Struct Dev 39, 124\u2013142 (2010).","journal-title":"Arthropod Struct Dev"},{"key":"e_1_3_4_68_2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.procbio.2010.02.019","article-title":"Biotransformation of procyanidins by a purified fungal dioxygenase: Identification and characterization of the products using mass spectrometry","volume":"45","author":"Roopesh K","year":"2010","unstructured":"K Roopesh, et al., Biotransformation of procyanidins by a purified fungal dioxygenase: Identification and characterization of the products using mass spectrometry. Process Biochem 45, 904\u2013913 (2010).","journal-title":"Process Biochem"},{"key":"e_1_3_4_69_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/08927022.2011.608672","article-title":"Dioxygenase from Aspergillus fumigatus MC8: Molecular modelling and in silico studies on enzyme-substrate interactions","volume":"38","author":"Roopesh K","year":"2012","unstructured":"K Roopesh, et al., Dioxygenase from Aspergillus fumigatus MC8: Molecular modelling and in silico studies on enzyme-substrate interactions. Mol Simul 38, 144\u2013151 (2012).","journal-title":"Mol Simul"},{"key":"e_1_3_4_70_2","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.cub.2006.07.052","article-title":"Evolution of filamentous plant pathogens: Gene exchange across eukaryotic kingdoms","volume":"16","author":"Richards TA","year":"2006","unstructured":"TA Richards, JB Dacks, JM Jenkinson, CR Thornton, NJ Talbot, Evolution of filamentous plant pathogens: Gene exchange across eukaryotic kingdoms. Curr Biol 16, 1857\u20131864 (2006).","journal-title":"Curr Biol"},{"key":"e_1_3_4_71_2","doi-asserted-by":"crossref","first-page":"15258","DOI":"10.1073\/pnas.1105100108","article-title":"Horizontal gene transfer facilitated the evolution of plant parasitic mechanisms in the oomycetes","volume":"108","author":"Richards TA","year":"2011","unstructured":"TA Richards, et al., Horizontal gene transfer facilitated the evolution of plant parasitic mechanisms in the oomycetes. Proc Natl Acad Sci USA 108, 15258\u201315263 (2011).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_72_2","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/j.febslet.2010.05.008","article-title":"A lipocalin sequence signature modulates cell survival","volume":"584","author":"Chudzinski-Tavassi AM","year":"2010","unstructured":"AM Chudzinski-Tavassi, et al., A lipocalin sequence signature modulates cell survival. FEBS Lett 584, 2896\u20132900 (2010).","journal-title":"FEBS Lett"},{"key":"e_1_3_4_73_2","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/ee\/12.4.1278","article-title":"Host-related alterations of detoxification enzymes in Tetranychus urticae (Acari: Tetranychidae)","volume":"12","author":"Mullin C","year":"1983","unstructured":"C Mullin, B Croft, Host-related alterations of detoxification enzymes in Tetranychus urticae (Acari: Tetranychidae). Environ Entomol 12, 1278\u20131282 (1983).","journal-title":"Environ Entomol"},{"key":"e_1_3_4_74_2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cub.2006.01.057","article-title":"Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan","volume":"16","author":"Walker DW","year":"2006","unstructured":"DW Walker, J Muffat, C Rundel, S Benzer, Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol 16, 674\u2013679 (2006).","journal-title":"Curr Biol"},{"key":"e_1_3_4_75_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2229-8-86","article-title":"The plant Apolipoprotein D ortholog protects Arabidopsis against oxidative stress","volume":"8","author":"Charron J-BF","year":"2008","unstructured":"J-BF Charron, F Ouellet, M Houde, F Sarhan, The plant Apolipoprotein D ortholog protects Arabidopsis against oxidative stress. BMC Plant Biol 8, 86 (2008).","journal-title":"BMC Plant Biol"},{"key":"e_1_3_4_76_2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1474-9726.2008.00395.x","article-title":"Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress","volume":"7","author":"Ganfornina MD","year":"2008","unstructured":"MD Ganfornina, et al., Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell 7, 506\u2013515 (2008).","journal-title":"Aging Cell"},{"key":"e_1_3_4_77_2","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/BF02035149","article-title":"Foliar oxidative stress and insect herbivory - Primary compounds, secondary metabolites, and reactive oxygen species as components of induced resistance","volume":"21","author":"Bi JL","year":"1995","unstructured":"JL Bi, GW Felton, Foliar oxidative stress and insect herbivory - Primary compounds, secondary metabolites, and reactive oxygen species as components of induced resistance. J Chem Ecol 21, 1511\u20131530 (1995).","journal-title":"J Chem Ecol"},{"key":"e_1_3_4_78_2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/jee\/79.6.1459","article-title":"Peroxidative responses of leaves in 2 soybean genotypes injured by 2-spotted spider-mites (Acari, Tetranychidae)","volume":"79","author":"Hildebrand DF","year":"1986","unstructured":"DF Hildebrand, JG Rodriguez, GC Brown, KT Luu, CS Volden, Peroxidative responses of leaves in 2 soybean genotypes injured by 2-spotted spider-mites (Acari, Tetranychidae). J Econ Entomol 79, 1459\u20131465 (1986).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_79_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.62.1.1-34.1998","article-title":"Major facilitator superfamily","volume":"62","author":"Pao SS","year":"1998","unstructured":"SS Pao, IT Paulsen, MH Saier, Major facilitator superfamily. Microbiol Mol Biol Rev 62, 1\u201334 (1998).","journal-title":"Microbiol Mol Biol Rev"},{"key":"e_1_3_4_80_2","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/j.1742-4658.2012.08588.x","article-title":"The major facilitator superfamily (MFS) revisited","volume":"279","author":"Reddy VS","year":"2012","unstructured":"VS Reddy, MA Shlykov, R Castillo, EI Sun, MH Saier, The major facilitator superfamily (MFS) revisited. FEBS J 279, 2022\u20132035 (2012).","journal-title":"FEBS J"},{"key":"e_1_3_4_81_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.mi.48.100194.002021","article-title":"Mechanisms underlying expression of Tn10 encoded tetracycline resistance","volume":"48","author":"Hillen W","year":"1994","unstructured":"W Hillen, C Berens, Mechanisms underlying expression of Tn10 encoded tetracycline resistance. Annu Rev Microbiol 48, 345\u2013369 (1994).","journal-title":"Annu Rev Microbiol"},{"key":"e_1_3_4_82_2","doi-asserted-by":"crossref","first-page":"e1000696","DOI":"10.1371\/journal.ppat.1000696","article-title":"Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea","volume":"5","author":"Kretschmer M","year":"2009","unstructured":"M Kretschmer, et al., Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea. PLoS Pathog 5, e1000696 (2009).","journal-title":"PLoS Pathog"},{"key":"e_1_3_4_83_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2174\/138945006777709575","article-title":"Microbial drug efflux proteins of the major facilitator superfamily","volume":"7","author":"Saidijam M","year":"2006","unstructured":"M Saidijam, et al., Microbial drug efflux proteins of the major facilitator superfamily. Curr Drug Targets 7, 793\u2013811 (2006).","journal-title":"Curr Drug Targets"},{"key":"e_1_3_4_84_2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jss.400100409","article-title":"Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cells","volume":"10","author":"Krieger M","year":"1979","unstructured":"M Krieger, et al., Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cells. J Supramol Struct 10, 467\u2013478 (1979).","journal-title":"J Supramol Struct"},{"key":"e_1_3_4_85_2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI200113992","article-title":"LRP: A multifunctional scavenger and signaling receptor","volume":"108","author":"Herz J","year":"2001","unstructured":"J Herz, DK Strickland, LRP: A multifunctional scavenger and signaling receptor. J Clin Invest 108, 779\u2013784 (2001).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_86_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/07853890701214881","article-title":"The LDL receptor-related protein (LRP) family: An old family of proteins with new physiological functions","volume":"39","author":"May P","year":"2007","unstructured":"P May, E Woldt, RL Matz, P Boucher, The LDL receptor-related protein (LRP) family: An old family of proteins with new physiological functions. Ann Med 39, 219\u2013228 (2007).","journal-title":"Ann Med"},{"key":"e_1_3_4_87_2","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1126\/science.1074170","article-title":"A single p450 allele associated with insecticide resistance in Drosophila","volume":"297","author":"Daborn PJ","year":"2002","unstructured":"PJ Daborn, et al., A single p450 allele associated with insecticide resistance in Drosophila. Science 297, 2253\u20132256 (2002).","journal-title":"Science"},{"key":"e_1_3_4_88_2","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1073\/pnas.0409348102","article-title":"The Anopheles gambiae detoxification chip: A highly specific microarray to study metabolic-based insecticide resistance in malaria vectors","volume":"102","author":"David JP","year":"2005","unstructured":"JP David, et al., The Anopheles gambiae detoxification chip: A highly specific microarray to study metabolic-based insecticide resistance in malaria vectors. Proc Natl Acad Sci USA 102, 4080\u20134084 (2005).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_89_2","doi-asserted-by":"crossref","first-page":"e8735","DOI":"10.1371\/journal.pone.0008735","article-title":"Unbiased transcriptional comparisons of generalist and specialist herbivores feeding on progressively defenseless Nicotiana attenuata plants","volume":"5","author":"Govind G","year":"2010","unstructured":"G Govind, et al., Unbiased transcriptional comparisons of generalist and specialist herbivores feeding on progressively defenseless Nicotiana attenuata plants. PLoS ONE 5, e8735 (2010).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_90_2","first-page":"10735","article-title":"Effect of the host plant on susceptibility of the two-spotted spider mite, Tetranychus urticae Koch, (Acari: Tetranychidae) to some acaricides","volume":"34","author":"Ibrahim MMS","year":"2009","unstructured":"MMS Ibrahim, Effect of the host plant on susceptibility of the two-spotted spider mite, Tetranychus urticae Koch, (Acari: Tetranychidae) to some acaricides. J Agric Sci Mansoura Univ 34, 10735\u201310744 (2009).","journal-title":"J Agric Sci Mansoura Univ"},{"key":"e_1_3_4_91_2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/jee\/43.5.633","article-title":"Natural and induced variations in two-spotted spider mite populations","volume":"43","author":"Neiswander CR","year":"1950","unstructured":"CR Neiswander, JG Rodriguez, RB Neiswander, Natural and induced variations in two-spotted spider mite populations. J Econ Entomol 43, 633\u2013636 (1950).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_92_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1086\/339463","article-title":"Induction of preference and performance after acclimation to novel hosts in a phytophagous spider mite: Adaptive plasticity?","volume":"159","author":"Agrawal AA","year":"2002","unstructured":"AA Agrawal, F Vala, MW Sabelis, Induction of preference and performance after acclimation to novel hosts in a phytophagous spider mite: Adaptive plasticity? Am Nat 159, 553\u2013565 (2002).","journal-title":"Am Nat"},{"key":"e_1_3_4_93_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00222792","article-title":"Causal connection between detoxification enzyme activity and consumption of a toxic plant compound","volume":"179","author":"Snyder MJ","year":"1996","unstructured":"MJ Snyder, JI Glendinning, Causal connection between detoxification enzyme activity and consumption of a toxic plant compound. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 179, 255\u2013261 (1996).","journal-title":"J Comp Physiol A Neuroethol Sens Neural Behav Physiol"},{"key":"e_1_3_4_94_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbapap.2010.06.012","article-title":"Arthropod CYPomes illustrate the tempo and mode in P450 evolution","volume":"1814","author":"Feyereisen R","year":"2011","unstructured":"R Feyereisen, Arthropod CYPomes illustrate the tempo and mode in P450 evolution. Biochim Biophys Acta 1814, 19\u201328 (2011).","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_4_95_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.en.32.010187.002045","article-title":"Ecological genetics of insecticide and acaricide resistance","volume":"32","author":"Roush RT","year":"1987","unstructured":"RT Roush, JA McKenzie, Ecological genetics of insecticide and acaricide resistance. Annu Rev Entomol 32, 361\u2013380 (1987).","journal-title":"Annu Rev Entomol"},{"key":"e_1_3_4_96_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0169-5347(94)90079-5","article-title":"The genetic, molecular and phenotypic consequences of selection for insecticide resistance","volume":"9","author":"McKenzie JA","year":"1994","unstructured":"JA McKenzie, P Batterham, The genetic, molecular and phenotypic consequences of selection for insecticide resistance. Trends Ecol Evol 9, 166\u2013169 (1994).","journal-title":"Trends Ecol Evol"},{"key":"e_1_3_4_97_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tig.2004.01.003","article-title":"The genetics and genomics of insecticide resistance","volume":"20","author":"ffrench-Constant RH","year":"2004","unstructured":"RH ffrench-Constant, PJ Daborn, G Le Goff, The genetics and genomics of insecticide resistance. Trends Genet 20, 163\u2013170 (2004).","journal-title":"Trends Genet"},{"key":"e_1_3_4_98_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ibmb.2012.03.002","article-title":"The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance","volume":"42","author":"Dermauw W","year":"2012","unstructured":"W Dermauw, et al., The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance. Insect Biochem Mol Biol 42, 455\u2013465 (2012).","journal-title":"Insect Biochem Mol Biol"},{"key":"e_1_3_4_99_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.en.30.010185.001245","article-title":"Genetic variation in the use of resources by insects","volume":"30","author":"Futuyma DJ","year":"1985","unstructured":"DJ Futuyma, SC Peterson, Genetic variation in the use of resources by insects. Annu Rev Entomol 30, 217\u2013238 (1985).","journal-title":"Annu Rev Entomol"},{"key":"e_1_3_4_100_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.en.35.010190.002225","article-title":"Ecological genetics and host adaptation in herbivorous insects: The experimental study of evolution in natural and agricultural systems","volume":"35","author":"Via S","year":"1990","unstructured":"S Via, Ecological genetics and host adaptation in herbivorous insects: The experimental study of evolution in natural and agricultural systems. Annu Rev Entomol 35, 421\u2013446 (1990).","journal-title":"Annu Rev Entomol"},{"key":"e_1_3_4_101_2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1558-5646.1979.tb04735.x","article-title":"Rapid host range evolution in a population of the phytophagous mite Tetranychus urticae Koch","volume":"33","author":"Gould F","year":"1979","unstructured":"F Gould, Rapid host range evolution in a population of the phytophagous mite Tetranychus urticae Koch. Evolution 33, 791\u2013802 (1979).","journal-title":"Evolution"},{"key":"e_1_3_4_102_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng.332","article-title":"Systems genetics of complex traits in Drosophila melanogaster","volume":"41","author":"Ayroles JF","year":"2009","unstructured":"JF Ayroles, et al., Systems genetics of complex traits in Drosophila melanogaster. Nat Genet 41, 299\u2013307 (2009).","journal-title":"Nat Genet"},{"key":"e_1_3_4_103_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1570-7458.2012.01249.x","article-title":"Transcriptional analysis of physiological pathways in a generalist herbivore: Responses to different host plants and plant structures by the cotton bollworm, Helicoverpa armigera","volume":"144","author":"Celorio-Mancera Mdl P","year":"2012","unstructured":"P Celorio-Mancera Mdl, DG Heckel, H Vogel, Transcriptional analysis of physiological pathways in a generalist herbivore: Responses to different host plants and plant structures by the cotton bollworm, Helicoverpa armigera. Entomol Exp Appl 144, 123\u2013133 (2012).","journal-title":"Entomol Exp Appl"},{"key":"e_1_3_4_104_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S0007485308006081","article-title":"Resistance mechanisms to mitochondrial electron transport inhibitors in a field-collected strain of Tetranychus urticae Koch (Acari: Tetranychidae)","volume":"99","author":"Van Pottelberge S","year":"2009","unstructured":"S Van Pottelberge, T Van Leeuwen, R Nauen, L Tirry, Resistance mechanisms to mitochondrial electron transport inhibitors in a field-collected strain of Tetranychus urticae Koch (Acari: Tetranychidae). Bull Entomol Res 99, 23\u201331 (2009).","journal-title":"Bull Entomol Res"},{"key":"e_1_3_4_105_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jee\/18.2.265a","article-title":"A method of computing the effectiveness of an insecticide","volume":"18","author":"Abbott WS","year":"1925","unstructured":"WS Abbott, A method of computing the effectiveness of an insecticide. J Econ Entomol 18, 265\u2013267 (1925).","journal-title":"J Econ Entomol"},{"key":"e_1_3_4_106_2","unstructured":"S Van Dongen Graph clustering by flow simulation. PhD thesis (Univ of Utrecht Utrecht The Netherlands). (2000)."},{"key":"e_1_3_4_107_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang W","year":"2009","unstructured":"W Huang, BT Sherman, RA Lempicki, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4, 44\u201357 (2009).","journal-title":"Nat Protoc"},{"key":"e_1_3_4_108_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul SF","year":"1990","unstructured":"SF Altschul, W Gish, W Miller, EW Myers, DJ Lipman, Basic local alignment search tool. J Mol Biol 215, 403\u2013410 (1990).","journal-title":"J Mol Biol"},{"key":"e_1_3_4_109_2","doi-asserted-by":"crossref","first-page":"D290","DOI":"10.1093\/nar\/gkr1065","article-title":"The Pfam protein families database","volume":"40","author":"Punta M","year":"2012","unstructured":"M Punta, et al., The Pfam protein families database. Nucleic Acids Res 40, D290\u2013D301 (2012).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_110_2","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and clustal X version 2.0","volume":"23","author":"Larkin MA","year":"2007","unstructured":"MA Larkin, et al., Clustal W and clustal X version 2.0. Bioinformatics 23, 2947\u20132948 (2007).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_111_2","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: Multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar RC","year":"2004","unstructured":"RC Edgar, MUSCLE: Multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32, 1792\u20131797 (2004).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_112_2","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/bioinformatics\/bti263","article-title":"ProtTest: Selection of best-fit models of protein evolution","volume":"21","author":"Abascal F","year":"2005","unstructured":"F Abascal, R Zardoya, D Posada, ProtTest: Selection of best-fit models of protein evolution. Bioinformatics 21, 2104\u20132105 (2005).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_113_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2148-4-18","article-title":"TREEFINDER: A powerful graphical analysis environment for molecular phylogenetics","volume":"4","author":"Jobb G","year":"2004","unstructured":"G Jobb, A von Haeseler, K Strimmer, TREEFINDER: A powerful graphical analysis environment for molecular phylogenetics. BMC Evol Biol 4, 18 (2004).","journal-title":"BMC Evol Biol"},{"key":"e_1_3_4_114_2","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura K","year":"2011","unstructured":"K Tamura, et al., MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28, 2731\u20132739 (2011).","journal-title":"Mol Biol Evol"},{"key":"e_1_3_4_115_2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0","volume":"340","author":"Bendtsen JD","year":"2004","unstructured":"JD Bendtsen, H Nielsen, G von Heijne, S Brunak, Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340, 783\u2013795 (2004).","journal-title":"J Mol Biol"},{"key":"e_1_3_4_116_2","doi-asserted-by":"crossref","first-page":"W197","DOI":"10.1093\/nar\/gkn238","article-title":"The Jpred 3 secondary structure prediction server","volume":"36","author":"Cole C","year":"2008","unstructured":"C Cole, JD Barber, GJ Barton, The Jpred 3 secondary structure prediction server. Nucleic Acids Res 36, W197\u2013W201 (2008).","journal-title":"Nucleic Acids Res"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1213214110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T06:08:15Z","timestamp":1654582095000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1213214110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,17]]},"references-count":121,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1,8]]}},"alternative-id":["10.1073\/pnas.1213214110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1213214110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,17]]},"assertion":[{"value":"2012-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}