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The initial step in the degradation of pentachlorophenol by\n                    <jats:italic>Sphingobium chlorophenolicum<\/jats:italic>\n                    generates a particularly toxic intermediate, tetrachlorobenzoquinone (TCBQ). This paper describes how the bacterium is protected from the toxic effects of TCBQ. In the presence of tetrachlorobenzoquinone reductase, TCBQ produced by pentachlorophenol hydroxylase is sequestered until it is reduced to the less toxic tetrachlorohydroquinone.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1214052110","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:29:36Z","timestamp":1368664176000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol"],"prefix":"10.1073","volume":"110","author":[{"given":"Itamar","family":"Yadid","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Hlouchova","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley D.","family":"Copley","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nchembio.197","article-title":"Evolution of efficient pathways for degradation of anthropogenic chemicals","volume":"5","author":"Copley SD","year":"2009","unstructured":"SD Copley, Evolution of efficient pathways for degradation of anthropogenic chemicals. 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