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In the present study, using mouse models, conditional cell lineage analysis has demonstrated that MCs expressing Wilms tumor 1 give rise to HSCs and myofibroblasts during liver fibrogenesis. Primary MCs, isolated from adult mouse liver using antibodies against glycoprotein M6a, undergo myofibroblastic transdifferentiation. Antagonism of TGF-\u03b2 signaling suppresses transition of MCs to mesenchymal cells both in vitro and in vivo. These results indicate that MCs undergo mesothelial\u2013mesenchymal transition and participate in liver injury via differentiation to HSCs and myofibroblasts.<\/jats:p>","DOI":"10.1073\/pnas.1214136110","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T05:03:36Z","timestamp":1359003816000},"page":"2324-2329","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":209,"title":["Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial\u2013mesenchymal transition in liver injury"],"prefix":"10.1073","volume":"110","author":[{"given":"Yuchang","family":"Li","sequence":"first","affiliation":[{"name":"Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinji","family":"Asahina","sequence":"additional","affiliation":[{"name":"Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,1,23]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1357-2725(03)00242-5","article-title":"The mesothelial cell","volume":"36","author":"Mutsaers SE","year":"2004","unstructured":"SE Mutsaers, The mesothelial cell. 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