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Here we show that the LDL receptor (LDLR) serves as the major entry port of VSV and of VSV-G-pseudotyped lentiviral vectors in human and mouse cells, whereas other LDLR family members serve as alternative receptors. The widespread expression of LDLR family members accounts for the pantropism of VSV and for the broad applicability of VSV-G-pseudotyped viral vectors for gene transduction.<\/jats:p>","DOI":"10.1073\/pnas.1214441110","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T21:53:08Z","timestamp":1366062788000},"page":"7306-7311","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":654,"title":["LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus"],"prefix":"10.1073","volume":"110","author":[{"given":"Danit","family":"Finkelshtein","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Werman","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Novick","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Barak","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menachem","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.03.003"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1181766"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5259.263"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00482-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-7534-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566523054546224"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.319"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652311795684740"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209042"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3474-3479.2001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.2.895-904.2002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.16.8843-8856.2003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21307"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.26"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00967.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00342-11"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2390"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.16.1.75-84.1975"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1456"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.42.1.220-227.1982"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.05.006"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.15.4.882-893.1975"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-9-2359"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90483-X"},{"key":"e_1_3_3_25_2","first-page":"10","article-title":"Role of sialic acid in cell receptors for vesicular stomatitis virus","volume":"30","author":"Superti F","year":"1986","unstructured":"F Superti, C Girmenta, L Seganti, N Orsi, Role of sialic acid in cell receptors for vesicular stomatitis virus. 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