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In addition, both Olfr78 and G protein-coupled receptor 41 (Gpr41), another SCFA receptor, are expressed in smooth muscle cells of small resistance vessels. Propionate, a SCFA shown to induce vasodilation ex vivo, produces an acute hypotensive response in wild-type mice. This effect is differentially modulated by disruption of Olfr78 and Gpr41 expression. SCFAs are end products of fermentation by the gut microbiota and are absorbed into the circulation. Antibiotic treatment reduces the biomass of the gut microbiota and elevates blood pressure in\n                    <jats:italic>Olfr78<\/jats:italic>\n                    knockout mice. We conclude that SCFAs produced by the gut microbiota modulate blood pressure via Olfr78 and Gpr41.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1215927110","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T22:48:58Z","timestamp":1360622938000},"page":"4410-4415","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1137,"title":["Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation"],"prefix":"10.1073","volume":"110","author":[{"given":"Jennifer L.","family":"Pluznick","sequence":"first","affiliation":[{"name":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Protzko","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haykanush","family":"Gevorgyan","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics and Medicine, University of Southern California, Los Angeles, CA 90033;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita","family":"Peterlin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Columbia University, New York, NY 10027;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Sipos","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Biophysics and Medicine, University of Southern California, Los Angeles, CA 90033;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinah","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Brunet","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research in Biology, College de France, 75231 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La-Xiang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Rey","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108; 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