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The Relish (Rel)-like transcription factors NF-\u03baB and NFATc were previously known to control specific points of thymocyte maturation. Our work now positions the Rel-like protein NFAT5 as a target of the IKK\u03b2 pathway in thymocytes and as a downstream effector of the prosurvival role of the pre-TCR through its ability to regulate the expression of the survival-promoting proteins A1 and Bcl2 and attenuate the proapoptotic axis comprised by p53 and Noxa proteins.<\/jats:p>","DOI":"10.1073\/pnas.1215934110","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T00:23:51Z","timestamp":1379377431000},"page":"16091-16096","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["NFAT5 induction by the pre\u2013T-cell receptor serves as a selective survival signal in T-lymphocyte development"],"prefix":"10.1073","volume":"110","author":[{"given":"Rosa","family":"Berga-Bola\u00f1os","sequence":"first","affiliation":[{"name":"Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alberdi","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Buxad\u00e9","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Aramburu","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"L\u00f3pez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.150.10.4244","article-title":"A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression","volume":"150","author":"Godfrey DI","year":"1993","unstructured":"DI Godfrey, J Kennedy, T Suda, A Zlotnik, A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. 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