{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:58:16Z","timestamp":1791316696303,"version":"4.3.1"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,2,26]]},"abstract":"<jats:p>\n                    The current epidemic of infections caused by antibiotic-resistant Gram-positive bacteria requires the discovery of new drug targets and the development of new therapeutics. Lipoteichoic acid (LTA), a cell wall polymer of Gram-positive bacteria, consists of 1,3-polyglycerol-phosphate linked to glycolipid. LTA synthase (LtaS) polymerizes polyglycerol-phosphate from phosphatidylglycerol, a reaction that is essential for the growth of Gram-positive bacteria. We screened small molecule libraries for compounds inhibiting growth of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    but not of Gram-negative bacteria. Compound 1771 [2-oxo-2-(5-phenyl-1,3,4-oxadiazol-2-ylamino)ethyl 2-naphtho[2,1-\n                    <jats:italic>b<\/jats:italic>\n                    ]furan-1-ylacetate] blocked phosphatidylglycerol binding to LtaS and inhibited LTA synthesis in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and in\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    expressing\n                    <jats:italic>ltaS<\/jats:italic>\n                    . Compound 1771 inhibited the growth of antibiotic-resistant Gram-positive bacteria and prolonged the survival of mice with lethal\n                    <jats:italic>S. aureus<\/jats:italic>\n                    challenge, validating LtaS as a target for the development of antibiotics.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1217337110","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T22:48:58Z","timestamp":1360622938000},"page":"3531-3536","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":114,"title":["Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria"],"prefix":"10.1073","volume":"110","author":[{"given":"Stefan G.","family":"Richter","sequence":"first","affiliation":[{"name":"Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, IL 60439;"},{"name":"Department of Microbiology, University of Chicago, Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Elli","sequence":"additional","affiliation":[{"name":"Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, IL 60439;"},{"name":"Department of Microbiology, University of Chicago, Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Howard Taylor Ricketts Laboratory, Argonne National Laboratory, Argonne, IL 60439;"},{"name":"Department of Microbiology, University of Chicago, Chicago, IL 60637; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni P. 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