{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:30:22Z","timestamp":1790829022440,"version":"4.1.0"},"reference-count":58,"publisher":"National Academy of Sciences","issue":"36","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,9,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>EV71 infection with severe neurological complications has become a serious public health concern. However, suitable small animal models to study human EV71 pathogenesis are not available. We have generated a Tg mouse model by expressing the human EV71 receptor, Scavenger receptor B2, and found it to be susceptible to EV71 infection. This Tg mouse model exhibits neurological disease and pathology very similar to that observed in humans. The results confirm that the Scavenger receptor B2 receptor is important for EV71 infection in vivo. Further development of this new small animal model should greatly contribute toward investigation of EV71 pathogenesis and development of vaccines and antiviral drugs.<\/jats:p>","DOI":"10.1073\/pnas.1217563110","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T21:59:24Z","timestamp":1376949564000},"page":"14753-14758","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":159,"title":["Transgenic mouse model for the study of enterovirus 71 neuropathogenesis"],"prefix":"10.1073","volume":"110","author":[{"given":"Ken","family":"Fujii","sequence":"first","affiliation":[{"name":"Neurovirology Project and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyo","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Institute of Infectious Diseases, Tokyo 208-0011, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Institute of Infectious Diseases, Tokyo 208-0011, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien Chai","family":"Ong","sequence":"additional","affiliation":[{"name":"Departments of cBiomedical Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kum Thong","family":"Wong","sequence":"additional","affiliation":[{"name":"Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Yamayoshi","sequence":"additional","affiliation":[{"name":"Neurovirology Project and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Shimanuki","sequence":"additional","affiliation":[{"name":"Laboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shitara","sequence":"additional","affiliation":[{"name":"Laboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choji","family":"Taya","sequence":"additional","affiliation":[{"name":"Laboratory for Transgenic Technology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Koike","sequence":"additional","affiliation":[{"name":"Neurovirology Project and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,8,19]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/129.3.304"},{"key":"e_1_3_3_2_2","unstructured":"Pallansch M Roos R (2007) Enteroviruses: Polioviruses Coxsackieviruses Echoviruses and newer Enteroviruses. Fields Virology eds Knipe DM et al. (Lippincott Williams & Wilkins Philadelphia) 5th Ed Vol 1 pp 839\u2013893."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411301"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411302"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2011.01247.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e318163a990"},{"key":"e_1_3_3_7_2","first-page":"284","article-title":"Epidemiological, clinical, and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by enterovirus 71","volume":"23","author":"Shindarov LM","year":"1979","unstructured":"LM Shindarov, et al., Epidemiological, clinical, and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by enterovirus 71. J Hyg Epidemiol Microbiol Immunol 23, 284\u2013295 (1979).","journal-title":"J Hyg Epidemiol Microbiol Immunol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01314873"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(99)00019-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318231d67a"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01317855"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691653"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1982.tb00269.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2209"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79883-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01317504"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19423-0"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.15.7916-7924.2004"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.04.004"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06103-11"},{"key":"e_1_3_3_21_2","first-page":"73","volume-title":"The Picornaviruses","author":"Bergelson JM","year":"2010","unstructured":"JM Bergelson, Receptors. The Picornaviruses, eds E Ehrenfeld, E Domingo, RP Roos (ASM Press, Washington, DC), pp. 73\u201386 (2010)."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90168-E"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.3.951"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1713"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-141"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00297-11"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1961"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1992"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00075"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.018"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02358-10"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00020-12"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02070-12"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021820"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg062"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300353-JLR200"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-011-1198-2"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195807242590408"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10453.x"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-8"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198702000-00013"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/6.Supplement_2.S387"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70155-6"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1086\/520149"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.06.044"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.11.087"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00999-09"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057591"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01310797"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1327"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.2.681-688.1994"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1030"},{"key":"e_1_3_3_53_2","first-page":"251","article-title":"Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: Validation by a WHO collaborative study","volume":"81","author":"Dragunsky E","year":"2003","unstructured":"E Dragunsky, et al., Transgenic mice as an alternative to monkeys for neurovirulence testing of live oral poliovirus vaccine: Validation by a WHO collaborative study. Bull World Health Organ 81, 251\u2013260 (2003).","journal-title":"Bull World Health Organ"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068284"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000412"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.52.12"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2004.01868.x"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-90-22088"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1217563110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:07:44Z","timestamp":1649801264000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1217563110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,19]]},"references-count":58,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2013,9,3]]}},"alternative-id":["10.1073\/pnas.1217563110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1217563110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,19]]},"assertion":[{"value":"2013-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}