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Bunyaviruses deliver their genome into the host-cell cytoplasm by fusing their envelope with an endosomal membrane. The molecular mechanism of this key entry step is unknown. The crystal structure of RVFV G\n                    <jats:sub>C<\/jats:sub>\n                    reveals a class II fusion protein architecture found previously in flaviviruses and alphaviruses. The structure identifies G\n                    <jats:sub>C<\/jats:sub>\n                    as the effector of membrane fusion and provides a direct view of the membrane anchor that initiates fusion. A structure of nonglycosylated G\n                    <jats:sub>C<\/jats:sub>\n                    reveals an extended conformation that may represent a fusion intermediate. Unanticipated similarities between G\n                    <jats:sub>C<\/jats:sub>\n                    and flavivirus envelope proteins reveal an evolutionary link between the two virus families and provide insights into the organization of G\n                    <jats:sub>C<\/jats:sub>\n                    in the outer shell of RVFV.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1217780110","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T23:55:05Z","timestamp":1358207705000},"page":"1696-1701","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":136,"title":["Crystal structure of glycoprotein C from Rift Valley fever virus"],"prefix":"10.1073","volume":"110","author":[{"given":"Moshe","family":"Dessau","sequence":"first","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorgo","family":"Modis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,1,14]]},"reference":[{"key":"e_1_3_4_1_2","volume-title":"Fields Virology","author":"Schmaljohn CS","year":"2007","unstructured":"CS Schmaljohn, ST Nichol, Bunyaviridae. 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