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This paper demonstrates that cell type-specific NF-\u03baB inhibition can be achieved using multi-modular fusion proteins, which exclusively target activated endothelial cells. Inhibition of NF-\u03baB within activated endothelium potently ameliorated peritonitis and arthritis in mice, indicating that endothelial NF-\u03baB might be a valid target in inflammatory diseases. Importantly, this strategy enables the targeting of other cell types and intracellular signaling pathways.<\/jats:p>","DOI":"10.1073\/pnas.1218219110","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T01:25:39Z","timestamp":1379985939000},"page":"16556-16561","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["NF-\u03baB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-\u03baB in immune-mediated diseases"],"prefix":"10.1073","volume":"110","author":[{"given":"Bettina","family":"Sehnert","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology and Centre of Chronic Immunodeficiency, University Medical Centre and University of Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine II and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Johann Wolfgang Goethe University Frankfurt am Main, 60590 Frankfurt am Main, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes T.","family":"Wessels","sequence":"additional","affiliation":[{"name":"Central Core Facility \u201cMolecular and Optical Live Cell Imaging\u201d, Department of Nephrology and Rheumatology, University Medicine, 37075 G\u00f6ttingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Clinical Research, Research Group N2, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"May","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Vestweber","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Molecular Biomedicine, 48149 M\u00fcnster, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Zwerina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Warnatz","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology and Centre of Chronic Immunodeficiency, University Medical Centre and University of Freiburg, 79106 Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Nimmerjahn","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Biology, University of Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany; 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