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To understand the functional significance of COUP-TFII expression in the steroidogenic factor 1 neurons, we generated hypothalamic ventromedial nucleus-specific COUP-TFII KO mice using the cyclization recombination\/locus of X-overP1 technology. The heterozygous mutant mice display insulin hypersensitivity and a leaner phenotype associated with increased energy expenditure and similar food intake. These mutant mice also present a defective counterregulation to hypoglycemia with altered glucagon secretion. Moreover, the mutant mice are more likely to develop hypoglycemia-associated autonomic failure in response to recurrent hypoglycemic or glucopenic events. Therefore, COUP-TFII expression levels in the ventromedial nucleus are keys in the ability to resist the onset of hypoglycemia-associated autonomic failure.<\/jats:p>","DOI":"10.1073\/pnas.1219262110","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:41:51Z","timestamp":1361839311000},"page":"4333-4338","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Hypothalamic ventromedial COUP-TFII protects against hypoglycemia-associated autonomic failure"],"prefix":"10.1073","volume":"110","author":[{"given":"Lina","family":"Sabra-Makke","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 1016, Institut Cochin, 75014 Paris, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 8104, 75014 Paris, France;"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 75014 Paris, France; 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