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Moreover, mAb hu2c neutralized HSV fully independent of complement and\/or immune effector cell recruitment in a highly efficient manner. Prophylactic and therapeutic administration of mAb hu2c completely prevented infection-related mortality of severely immunodeficient mice being challenged with a lethal dose of HSV-1. The high neutralization capacity of mAb hu2c was fully maintained toward clinical HSV isolates being multiresistant to standard antiviral drugs, and infection was fully resolved in 7\/8 nonobese diabetic\/SCID mice being infected with a multidrug resistant HSV-1 patient isolate. Immunohistochemical studies revealed no significant cross-reactivity of the antibody toward human tissues. These features warrant further clinical development of mAb hu2c as an immunotherapeutic compound for the management of severe and particularly drug-resistant HSV infections.<\/jats:p>","DOI":"10.1073\/pnas.1220019110","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T21:18:31Z","timestamp":1365455911000},"page":"6760-6765","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":88,"title":["Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody"],"prefix":"10.1073","volume":"110","author":[{"given":"Adalbert","family":"Krawczyk","sequence":"first","affiliation":[{"name":"Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany;"},{"name":"National Center for Tumor Diseases and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela A. 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