{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:42:17Z","timestamp":1791420137664,"version":"4.3.3"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"31","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,7,30]]},"abstract":"<jats:p>The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active and inactive form is tightly controlled to ensure cellular integrity. We report that the transcriptional repressor CTIP2 is a major modulator of P-TEFb activity. CTIP2 copurifies and interacts with an inactive P-TEFb complex containing the 7SK snRNA and HEXIM1. CTIP2 associates directly with HEXIM1 and, via the loop 2 of the 7SK snRNA, with P-TEFb. In this nucleoprotein complex, CTIP2 significantly represses the Cdk9 kinase activity of P-TEFb. Accordingly, we show that CTIP2 inhibits large sets of P-TEFb- and 7SK snRNA-sensitive genes. In hearts of hypertrophic cardiomyopathic mice, CTIP2 controls P-TEFb-sensitive pathways involved in the establishment of this pathology. Overexpression of the \u03b2-myosin heavy chain protein contributes to the pathological cardiac wall thickening. The inactive P-TEFb complex associates with CTIP2 at the MYH7 gene promoter to repress its activity. Taken together, our results strongly suggest that CTIP2 controls P-TEFb function in physiological and pathological conditions.<\/jats:p>","DOI":"10.1073\/pnas.1220136110","type":"journal-article","created":{"date-parts":[[2013,7,13]],"date-time":"2013-07-13T01:40:16Z","timestamp":1373679616000},"page":"12655-12660","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":98,"title":["CTIP2 is a negative regulator of P-TEFb"],"prefix":"10.1073","volume":"110","author":[{"given":"Thomas","family":"Cherrier","sequence":"first","affiliation":[{"name":"Institut de Parasitologie et de Pathologie Tropicale, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle, University of Strasbourg, 67000 Strasbourg, France;"},{"name":"Laboratory of Protein Signaling and Interactions, University of Li\u00e8ge, Li\u00e8ge, Belgium,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Le Douce","sequence":"additional","affiliation":[{"name":"Institut de Parasitologie et de Pathologie Tropicale, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle, University of Strasbourg, 67000 Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Eilebrecht","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 955, 94010 Cr\u00e9teil, France;"},{"name":"Institut des Hautes \u00c9tudes Scientifiques, Centre National de la Recherche Scientifique, 91440 Bures sur Yvette, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Riclet","sequence":"additional","affiliation":[{"name":"Institut de Parasitologie et de Pathologie Tropicale, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle, University of Strasbourg, 67000 Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Marban","sequence":"additional","affiliation":[{"name":"Institut de Parasitologie et de Pathologie Tropicale, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle, University of Strasbourg, 67000 Strasbourg, France;"},{"name":"Department of Biological Chemistry, University of California, Los Angeles, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Dequiedt","sequence":"additional","affiliation":[{"name":"Laboratory of Protein Signaling and Interactions, University of Li\u00e8ge, Li\u00e8ge, Belgium,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Goumon","sequence":"additional","affiliation":[{"name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives, University of Strasbourg, Centre National de la Recherche Scientifique, 67000 Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Paillart","sequence":"additional","affiliation":[{"name":"Architecture et R\u00e9activit\u00e9 de l'ARN, Centre National de la Recherche Scientifique Unit\u00e9 Propre de Recherche 9002, Institut de Biologie Mol\u00e9culaire et Cellulaire, Universit\u00e9 de Strasbourg, 67000 Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Mericskay","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche 4, Aging, Stress, Inflammation Department, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 6, 75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ara","family":"Parlakian","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche 4, Aging, Stress, Inflammation Department, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 6, 75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Bausero","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche 4, Aging, Stress, Inflammation Department, Universit\u00e9 Pierre et Marie Curie Universit\u00e9 Paris 6, 75005 Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasim","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Virology, Institut F\u00e9d\u00e9ratif de Recherche 133, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University of Franche-Comt\u00e9, 25000 Besan\u00e7on, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Herbein","sequence":"additional","affiliation":[{"name":"Department of Virology, Institut F\u00e9d\u00e9ratif de Recherche 133, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, University of Franche-Comt\u00e9, 25000 Besan\u00e7on, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siavash K.","family":"Kurdistani","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, University of California, Los Angeles, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Grana","sequence":"additional","affiliation":[{"name":"Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Van Driessche","sequence":"additional","affiliation":[{"name":"Institut de Biologie et de M\u00e9decine Mol\u00e9culaires, Universit\u00e9 Libre de Bruxelles, 6041 Gosselies, Belgium; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Institut de Parasitologie et de Pathologie Tropicale, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle, University of Strasbourg, 67000 Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Candolfi","sequence":"additional","affiliation":[{"name":"Institut de Parasitologie et de Pathologie Tropicale, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle, University of Strasbourg, 67000 Strasbourg, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt G.","family":"Benecke","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 955, 94010 Cr\u00e9teil, France;"},{"name":"Institut des Hautes \u00c9tudes Scientifiques, Centre National de la Recherche Scientifique, 91440 Bures sur Yvette, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Van Lint","sequence":"additional","affiliation":[{"name":"Institut de Biologie et de M\u00e9decine Mol\u00e9culaires, Universit\u00e9 Libre de Bruxelles, 6041 Gosselies, Belgium; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rohr","sequence":"additional","affiliation":[{"name":"Institut de Parasitologie et de Pathologie Tropicale, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle, University of Strasbourg, 67000 Strasbourg, France;"},{"name":"Institut Universitaire de France, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.21.12335"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.17.6594"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00011-06"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21938"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.06.027"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.06.029"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600275"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35104581"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/35104575"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00388-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.04.013"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.04.012"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1827"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188995"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188989"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.036"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900568106"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005367"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601516"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201101100"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2193"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.9.5415-5427.2003"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014304108"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188063"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2246"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.193"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki529"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207972"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1398206"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80939-3"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1153"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.1.14261"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.6.17015"},{"key":"e_1_3_3_34_2","doi-asserted-by":"crossref","unstructured":"S Eilebrecht C Schwartz O Rohr Non-coding RNAs: Novel players in chromatin-regulation during viral latency. Curr Opin Virol 10.1016\/j.coviro.2013.04.001. (2013).","DOI":"10.1016\/j.coviro.2013.04.001"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.6.2.8115"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr857"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.028"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)11792-H"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602776200"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.23686"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-0229(10)60006-X"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-0229(06)60021-1"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-6-307"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-0229(07)60002-3"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2012.06.002"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1220136110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T22:04:24Z","timestamp":1650060264000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1220136110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":45,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2013,7,30]]}},"alternative-id":["10.1073\/pnas.1220136110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1220136110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,12]]},"assertion":[{"value":"2013-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}