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The current study challenges this proposal and clearly shows that lipoproteins containing apoE isoforms are unlikely to play a significant role in A\u03b2 metabolism by binding directly to A\u03b2 in physiological fluids such as cerebrospinal fluid or interstitial fluid. Our in vitro and in vivo results suggest that apoE isoforms influence A\u03b2 metabolism by competing for the same clearance pathways within the brain.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1220484110","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:30:50Z","timestamp":1366936250000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":528,"title":["ApoE influences amyloid-\u03b2 (A\u03b2) clearance despite minimal apoE\/A\u03b2 association in physiological conditions"],"prefix":"10.1073","volume":"110","author":[{"given":"Philip B.","family":"Verghese","sequence":"first","affiliation":[{"name":"Departments of aNeurology,"},{"name":"Hope Center for Neurological Disorders, and"},{"name":"The Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110; 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