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Here we studied some phenotypic features of a well-established animal model of type 2 diabetes, the leptin receptor-deficient\n                    <jats:italic>db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:italic>\/db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    mouse, and also the effect of long-term (6 mo) treatment with coenzyme Q10 (CoQ10), an endogenous antioxidant. Diabetic mice at 8 mo of age exhibited loss of sensation, hypoalgesia (an increase in mechanical threshold), and decreases in mechanical hyperalgesia, cold allodynia, and sciatic nerve conduction velocity. All these changes were virtually completely absent after the 6-mo, daily CoQ10 treatment in\n                    <jats:italic>db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:italic>\/db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    mice when started at 7 wk of age. There was a 33% neuronal loss in the lumbar 5 dorsal root ganglia (DRGs) of the\n                    <jats:italic>db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:italic>\/db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    mouse versus controls at 8 mo of age, which was significantly attenuated by CoQ10. There was no difference in neuron number in 5\/6-wk-old mice between diabetic and control mice. We observed a strong down-regulation of phospholipase C (PLC) \u03b23 in the DRGs of diabetic mice at 8 mo of age, a key molecule in pain signaling, and this effect was also blocked by the 6-mo CoQ10 treatment. Many of the phenotypic, neurochemical regulations encountered in lumbar DRGs in standard models of peripheral nerve injury were not observed in diabetic mice at 8 mo of age. These results suggest that reactive oxygen species and reduced PLC\u03b23 expression may contribute to the sensory deficits in the late-stage diabetic\n                    <jats:italic>db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:italic>\/db<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    mouse, and that early long-term administration of the antioxidant CoQ10 may represent a promising therapeutic strategy for type 2 diabetes neuropathy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1220794110","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T23:14:38Z","timestamp":1356390878000},"page":"690-695","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":67,"title":["Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the\n                    <i>db<\/i>\n                    <sup>\u2212<\/sup>\n                    <i>\/db<\/i>\n                    <sup>\u2212<\/sup>\n                    mouse, a type 2 diabetes model"],"prefix":"10.1073","volume":"110","author":[{"given":"Tie-Jun Sten","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden;"},{"name":"School of Life Science and Technology, Harbin Institute of Technology, 150001 Harbin, China;"},{"name":"Department of Neuroscience,"},{"name":"Department of Dental Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Harbin Institute of Technology, 150001 Harbin, China;"},{"name":"Department of Neuroscience,"},{"name":"Department of Dental Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Zeberg","sequence":"additional","affiliation":[{"name":"Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Gr\u00fcnler","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Harbin Institute of Technology, 150001 Harbin, China;"},{"name":"Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj J.","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiu Bogdan","family":"Catrina","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"\u00c5rhem","sequence":"additional","affiliation":[{"name":"Department of Neuroscience,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Brismar","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas G. 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