{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:44:39Z","timestamp":1792129479847,"version":"4.4.0"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"12","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,6,11]]},"abstract":"<jats:p>\n                    Long-term depression (LTD) at cerebellar parallel fiber (PF)-Purkinje cell synapses must be balanced by long-term potentiation (LTP) to prevent saturation and allow reversal of motor learning. The only previously analyzed form of cerebellar LTP is induced by 4\u20138 Hz PF stimulation and requires cAMP but not nitric oxide. It is a poor candidate to reverse LTD because it is presynaptically expressed whereas LTD is postsynaptic. We now characterize a new form of LTP induced by 1 Hz PF stimulation for at least 300 s. This LTP is postsynaptically expressed, enhanced by chelating postsynaptic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , and depends on nitric oxide but not cAMP or cGMP, making it a plausible anti-Hebbian counterpart to Hebbian LTD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.122206399","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:46:49Z","timestamp":1027680409000},"page":"8389-8393","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":289,"title":["A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP"],"prefix":"10.1073","volume":"99","author":[{"given":"Varda","family":"Lev-Ram","sequence":"first","affiliation":[{"name":"Department of Pharmacology and The Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647; and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and The Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647; and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Storm","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and The Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647; and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Y.","family":"Tsien","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and The Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0647; and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,6,4]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80978-2"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81397-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5265.1126"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1143"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130414597"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90044-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80340-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-09-02881.1996"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00961.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00154-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00070-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-14-05516.2000"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016881"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.9.3383"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018380"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80079-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80099-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-22-08687.1997"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-23-10221.1999"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80500-0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.6.3151"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580998"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37368-4"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)80036-2"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00115a013"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/364626a0"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja962839d"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00825.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.19.030196.002253"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.2.781"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90130-6"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90269-0"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80310-4"},{"key":"e_1_3_3_34_2","first-page":"H208","volume":"273","author":"Yao J A","year":"1997","unstructured":"J A Yao, M Jiang, G N Tseng Am J Physiol 273, H208\u2013H219 (1997).","journal-title":"Am J Physiol"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.108.4.277"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.11958"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-01-00048.1999"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/25541"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00099-4"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.18.030195.001535"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-14-05366.1998"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.14009"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00246-X"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.122206399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:15:47Z","timestamp":1649801747000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.122206399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,4]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,6,11]]}},"alternative-id":["10.1073\/pnas.122206399"],"URL":"https:\/\/doi.org\/10.1073\/pnas.122206399","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,4]]},"assertion":[{"value":"2002-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}