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Despite the fact that in vitro experiments indicate that many synaptic proteins can be palmitoylated by more than one palmitoyl acyltransferase (PAT), the enzymes responsible for palmitoylation, we describe in this paper various synaptic, plastic, and cognitive consequences that result from constitutive loss of a single PAT, namely Hip14\/DHHC17. This reveals an important functional role for this PAT that cannot be compensated for by other existing PATs.<\/jats:p>","DOI":"10.1073\/pnas.1222384110","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:14:48Z","timestamp":1385424888000},"page":"20296-20301","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":53,"title":["Memory and synaptic deficits in\n                    <i>Hip14\/DHHC17<\/i>\n                    knockout mice"],"prefix":"10.1073","volume":"110","author":[{"given":"Austen J.","family":"Milnerwood","sequence":"first","affiliation":[{"name":"Department of Psychiatry and"},{"name":"Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z3;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and"},{"name":"Brain Research Centre, 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