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We found that the antimycotic agent flucytosine inhibits the expression of the iron-starvation \u03c3-factor PvdS, thereby repressing the production of major\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    virulence factors, namely pyoverdine, PrpL protease, and exotoxin A. Flucytosine administration at clinically meaningful dosing regimens suppressed\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    pathogenicity in a mouse model of lung infection. The in vitro and in vivo activity of flucytosine against\n                    <jats:italic>P. aeruginosa,<\/jats:italic>\n                    combined with its desirable pharmacological properties, paves the way for clinical trials on the anti-\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    efficacy of flucytosine in humans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1222706110","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T21:18:31Z","timestamp":1365455911000},"page":"7458-7463","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":151,"title":["Repurposing the antimycotic drug flucytosine for suppression of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    pathogenicity"],"prefix":"10.1073","volume":"110","author":[{"given":"Francesco","family":"Imperi","sequence":"first","affiliation":[{"name":"Department of Biology and Biotechnology \u201cC. Darwin\u201d, Sapienza University of Rome, 000185 Rome, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Massai","sequence":"additional","affiliation":[{"name":"Department of Sciences, University \u201cRoma Tre\u201d, 00146 Rome, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Facchini","sequence":"additional","affiliation":[{"name":"Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Frangipani","sequence":"additional","affiliation":[{"name":"Department of Sciences, University \u201cRoma Tre\u201d, 00146 Rome, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Visaggio","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cC. 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