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These pedigrees included 2,092 siblings of centenarians, whose survival was compared with 1900 birth cohort survival data from the U.S. Social Security Administration. Siblings of centenarians experienced a mortality advantage throughout their lives relative to the U.S. 1900 cohort. Female siblings had death rates at all ages about one-half the national level; male siblings had a similar advantage at most ages, although diminished somewhat during adolescence and young adulthood. Relative survival probabilities for these siblings increase markedly at older ages, reflecting the cumulative effect of their mortality advantage throughout life. Compared with the U.S. 1900 cohort, male siblings of centenarians were at least 17 times as likely to attain age 100 themselves, while female siblings were at least 8 times as likely.<\/jats:p>","DOI":"10.1073\/pnas.122587599","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:46:49Z","timestamp":1027680409000},"page":"8442-8447","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":298,"title":["Life-long sustained mortality advantage of siblings of centenarians"],"prefix":"10.1073","volume":"99","author":[{"given":"Thomas T.","family":"Perls","sequence":"first","affiliation":[{"name":"Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118; Department of Demography, University of California, Berkeley, CA 94720; Indiana University School of Medicine, Indianapolis, IN 46202; Centagenetix, Cambridge, MA 02139; and Howard Hughes Medical Institute, Genetics Division, Children's Hospital and Harvard Medical School, Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wilmoth","sequence":"additional","affiliation":[{"name":"Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118; Department of Demography, University of California, Berkeley, CA 94720; Indiana University School of Medicine, Indianapolis, IN 46202; Centagenetix, Cambridge, MA 02139; and Howard Hughes Medical Institute, Genetics Division, Children's Hospital and Harvard Medical School, Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Levenson","sequence":"additional","affiliation":[{"name":"Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118; Department of Demography, University of California, Berkeley, CA 94720; Indiana University School of Medicine, Indianapolis, IN 46202; Centagenetix, Cambridge, MA 02139; and Howard Hughes Medical Institute, Genetics Division, Children's Hospital and Harvard Medical School, Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Drinkwater","sequence":"additional","affiliation":[{"name":"Geriatrics Section, Boston Medical Center and Boston University Medical School, Boston, MA 02118; 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