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A total of 35% of MT\/ret mice develop a vitiligo, a skin depigmentation attributable to the lysis of normal melanocytes, associated with a delay in tumor progression. Here, we find that regulatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells accumulate in the skin, the spleen, and tumor-draining lymph nodes of MT\/ret mice not developing vitiligo. Regulatory T-cell depletion and IL-10 neutralization led to increased occurrence of vitiligo that correlated with a decreased incidence of melanoma metastases. In contrast, inflammatory monocytes\/dendritic cells accumulate in the skin of MT\/ret mice with active vitiligo. Moreover, they inhibit tumor cell proliferation in vitro through a reactive oxygen species-dependent mechanism, and both their depletion and reactive oxygen species neutralization in vivo increased tumor cell dissemination. Altogether, our data suggest that regulatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells favor tumor progression, in part, by inhibiting recruitment and\/or differentiation of inflammatory monocytes in the skin.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1300314110","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T23:53:19Z","timestamp":1374537199000},"page":"13085-13090","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1073","volume":"110","author":[{"given":"Arnaud","family":"Pommier","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 8104,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1016, and"},{"name":"Paris Descartes University, Cochin Hospital, 75014 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Audemard","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 8104,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1016, and"},{"name":"Paris Descartes University, Cochin Hospital, 75014 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Durand","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 8104,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1016, and"},{"name":"Paris Descartes University, Cochin Hospital, 75014 Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Lengagne","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 8104,"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1016, and"},{"name":"Paris Descartes University, Cochin Hospital, 75014 Paris, France; 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