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Moreover, autoantibodies contribute to joint inflammation in inflammatory arthritis by triggering cellular fragment crystallizable (Fc)\u03b3 receptors (Fc\u03b3R), resulting in the release of proinflammatory cytokines and chemokines essential for recruitment and activation of innate immune effector cells. In contrast, little is known about the expression pattern and function of different Fc\u03b3Rs during osteoclast differentiation. This would allow osteoclasts to directly interact with autoantibody immune complexes, rather than being influenced indirectly via proinflammatory cytokines released upon immune complex binding to other Fc\u03b3R-expressing innate immune cells. To address this question, we studied Fc\u03b3R expression and function on osteoclasts during the steady state and during acute joint inflammation in a model of inflammatory arthritis. Our results suggest that osteoclastogenesis is directly influenced by IgG autoantibody binding to select activating Fc\u03b3Rs on immature osteoclasts, resulting in enhanced osteoclast generation and, ultimately, bone destruction.<\/jats:p>","DOI":"10.1073\/pnas.1301001110","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T00:02:47Z","timestamp":1370908967000},"page":"10729-10734","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":166,"title":["Inflammatory monocytes and Fc\u03b3 receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice"],"prefix":"10.1073","volume":"110","author":[{"given":"Michaela","family":"Seeling","sequence":"first","affiliation":[{"name":"Institute of Genetics, Department of Biology, University of Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Hillenhoff","sequence":"additional","affiliation":[{"name":"Institute for General Zoology and Endocrinology, University of Ulm, 89081 Ulm, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre","family":"David","sequence":"additional","affiliation":[{"name":"Institute for Osteology and Biomechanics, University of Hamburg, 22529 Hamburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital of Erlangen, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tuckermann","sequence":"additional","affiliation":[{"name":"Institute for General Zoology and Endocrinology, University of Ulm, 89081 Ulm, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lux","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Department of Biology, University of Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Nimmerjahn","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Department of Biology, University of Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,6,10]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3669"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(04)82005-4"},{"key":"e_1_3_3_4_2","first-page":"105","article-title":"Fc\u03b3Rs in health and disease","volume":"350","author":"Nimmerjahn F","year":"2011","unstructured":"F Nimmerjahn, JV Ravetch, Fc\u03b3Rs in health and disease. 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