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Of the cytokines, only TNF selectively converted normal fibroblasts from the palm of patients with Dupuytren's disease into myofibroblasts via activation of the Wnt signaling pathway. Conversely, blockade of TNF resulted in reversal of the myofibroblast phenotype. Therefore, TNF inhibition may prevent progression or recurrence of Dupuytren's disease.<\/jats:p>","DOI":"10.1073\/pnas.1301100110","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T01:56:59Z","timestamp":1361325419000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":141,"title":["Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target"],"prefix":"10.1073","volume":"110","author":[{"given":"Liaquat S.","family":"Verjee","sequence":"first","affiliation":[{"name":"Kennedy Institute of Rheumatology, University of Oxford, London W6 8LH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S. 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