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We previously demonstrated that the injection of brain extracts from human mutant P301S tau-expressing transgenic mice into the brains of mice transgenic for wild-type human tau (line ALZ17) resulted in the assembly of wild-type human tau into filaments and the spreading of tau inclusions from the injection sites to anatomically connected brain regions. Here we injected brain extracts from humans who had died with various tauopathies into the hippocampus and cerebral cortex of ALZ17 mice. Argyrophilic tau inclusions formed in all cases and following the injection of the corresponding brain extracts, we recapitulated the hallmark lesions of AGD, PSP and CBD. Similar inclusions also formed after intracerebral injection of brain homogenates from human tauopathies into nontransgenic mice. Moreover, the induced formation of tau aggregates could be propagated between mouse brains. These findings suggest that once tau aggregates have formed in discrete brain areas, they become self-propagating and spread in a prion-like manner.<\/jats:p>","DOI":"10.1073\/pnas.1301175110","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T01:03:59Z","timestamp":1369098239000},"page":"9535-9540","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":749,"title":["Brain homogenates from human tauopathies induce tau inclusions in mouse brain"],"prefix":"10.1073","volume":"110","author":[{"given":"Florence","family":"Clavaguera","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Institute of Pathology, University Hospital, 4031 Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Akatsu","sequence":"additional","affiliation":[{"name":"Choju Medical Institute, Fukushimura Hospital, Toyohashi City 441-8124, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Fraser","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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