{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:09Z","timestamp":1791276909174,"version":"4.1.0"},"reference-count":65,"publisher":"National Academy of Sciences","issue":"26","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,6,25]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality, is a devastating neurodegenerative disease caused by reduced levels of Survival Motor Neuron (SMN) gene activity. Despite well-characterized aspects of the involvement of SMN in small nuclear ribonucleoprotein biogenesis, the gene circuitry affecting SMN activity remains obscure. Here, we use\n                    <jats:italic>Drosophila<\/jats:italic>\n                    as a model system to integrate results from large-scale genetic and proteomic studies and bioinformatic analyses to define a unique SMN interactome to provide a basis for a better understanding of SMA. Such efforts not only help dissect\n                    <jats:italic>Smn<\/jats:italic>\n                    biology but also may point to potential clinically relevant targets.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1301738110","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T21:14:26Z","timestamp":1370985266000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["Genetic circuitry of\n                    <i>Survival motor neuron<\/i>\n                    , the gene underlying spinal muscular atrophy"],"prefix":"10.1073","volume":"110","author":[{"given":"Anindya","family":"Sen","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas N.","family":"Dimlich","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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