{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:58Z","timestamp":1790741998936,"version":"4.1.0"},"reference-count":54,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,6,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Cancer stem cells (CSCs) frequently acquire the ability to self-renew and persist in their hosts by coopting normal stem cell programs. Blast crisis (BC) chronic myeloid leukemia is a prototypic example, as the acquired activation of \u03b2-catenin signaling that enables BC CSC function is also important in normal hematopoietic stem cell maintenance. In identifying eIF4E phosphorylation by the MNK kinases as a necessary step in \u03b2-catenin activation in BC CSCs, but not normal hematopoietic stem cells, we define a therapeutic target in BC. Our studies suggest that clinical trials with MNK kinase inhibitors are warranted in BC chronic myeloid leukemia.<\/jats:p>","DOI":"10.1073\/pnas.1301838110","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T01:30:32Z","timestamp":1370395832000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":125,"title":["Targeting of the MNK\u2013eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function"],"prefix":"10.1073","volume":"110","author":[{"given":"Sharon","family":"Lim","sequence":"first","affiliation":[{"name":"Cancer and Stem Cell Biology Program, Duke\u2013National University of Singapore Graduate Medical School, Singapore 169857;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzuen Yih","family":"Saw","sequence":"additional","affiliation":[{"name":"Cancer and Stem Cell Biology Program, Duke\u2013National University of Singapore Graduate Medical School, Singapore 169857;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California, Irvine, CA 92868;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Janes","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Department of Molecular Biology &amp; Biochemistry, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassoum","family":"Nacro","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*Star), Singapore 138669;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Hill","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*Star), Singapore 138669;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An Qi","family":"Lim","sequence":"additional","affiliation":[{"name":"Cancer and Stem Cell Biology Program, Duke\u2013National University of Singapore Graduate Medical School, Singapore 169857;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Tien","family":"Chang","sequence":"additional","affiliation":[{"name":"Cancer and Stem Cell Biology Program, Duke\u2013National University of Singapore Graduate Medical School, Singapore 169857;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fruman","sequence":"additional","affiliation":[{"name":"Institute for Immunology and Department of Molecular Biology &amp; Biochemistry, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Rizzieri","sequence":"additional","affiliation":[{"name":"Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yong","family":"Tan","sequence":"additional","affiliation":[{"name":"Departments of fPathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California, Irvine, CA 92868;"},{"name":"Institute for Immunology and Department of Molecular Biology &amp; Biochemistry, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T. 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