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In this study, we put forth a strategy to address the underlying inflammatory imbalance in periodontal disease by harnessing the body\u2019s own sophisticated immunoregulatory mechanisms through the recruitment of regulatory T cells (Tregs). This is accomplished by controllably releasing small quantities (nanogram\/kilogram range) of chemokine recognized by Tregs using biodegradable, resorbable polymers with an excellent track record of regulatory approval. Administration of Treg-recruiting treatments to the gingiva of mice and canines reduces clinical scores of disease as well as hard and soft tissue destruction.<\/jats:p>","DOI":"10.1073\/pnas.1302829110","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:37:12Z","timestamp":1383003432000},"page":"18525-18530","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":182,"title":["Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes"],"prefix":"10.1073","volume":"110","author":[{"given":"Andrew J.","family":"Glowacki","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261;"},{"name":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219;"},{"name":"Center for Craniofacial Regeneration, University of Pittsburgh, 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