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Here, we show that small cholesterol fractions reduce the viscosity of model lung surfactant interfaces by orders of magnitude while leaving compressibility and collapse unchanged, offering control over surfactant spreadability. Lipid\u2013cholesterol nanodomain complexes are observed, which act as line-active sources of free area to reduce surface viscosity.<\/jats:p>","DOI":"10.1073\/pnas.1303304110","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T03:25:22Z","timestamp":1375241122000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":90,"title":["Effect of cholesterol nanodomains on monolayer morphology and dynamics"],"prefix":"10.1073","volume":"110","author":[{"given":"KyuHan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University of California, Santa Barbara, CA 93106; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyoung Q.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Zell","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of California, Santa Barbara, CA 93106; 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