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Here we show that\n                    <jats:italic>Shigella<\/jats:italic>\n                    drastically modifies the degree of acylation of the lipid A moiety of LPS during host cell invasion. The purified hypoacylated LPS displays a reduced inflammatory potential that allows the bacteria to lower the sensing activity of the immune system and to escape from downstream effector mechanisms.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1303641110","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T23:37:12Z","timestamp":1383003432000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":114,"title":["Intracellular\n                    <i>Shigella<\/i>\n                    remodels its LPS to dampen the innate immune recognition and evade inflammasome activation"],"prefix":"10.1073","volume":"110","author":[{"given":"Ida","family":"Paciello","sequence":"first","affiliation":[{"name":"Dipartimento di Biologia e Biotecnologie C. Darwin and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Silipo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Universit\u00e0 di Napoli Federico II, Complesso Universitario Monte Santangelo, 80126 Naples, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Lembo-Fazio","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Biotecnologie C. Darwin and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Curcur\u00f9","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Biotecnologie C. Darwin and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zumsteg","sequence":"additional","affiliation":[{"name":"Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin 10117, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Biotecnologie C. Darwin and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Ciancarella","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Biotecnologie C. 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