{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:31:56Z","timestamp":1793266316543,"version":"4.5.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"47","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,11,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The gene responsible for the X-linked form of Opitz syndrome (OS),\n                    <jats:italic>Midline-1<\/jats:italic>\n                    (\n                    <jats:italic>MID1<\/jats:italic>\n                    ), encodes an E3 ubiquitin ligase and was reported to guide the degradation of the catalytic subunit of protein phosphatase 2A (PP2Ac). But whether and how it is involved in neural development is unclear. We demonstrate here that Mid1-dependent PP2Ac turnover is involved in axon development. Knocking down or knocking out Mid1 not only promotes axon growth and branching in vitro, but also accelerates axon elongation and disrupts the pattern of callosal projection in mouse cortex. These defects can be reversed by down-regulating the accumulated PP2Ac in Mid1-depleted cells. Dysfunction of this Mid1\u2013PP2Ac pathway may underlie neural symptoms of OS patients.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1303687110","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T20:16:06Z","timestamp":1383682566000},"page":"19131-19136","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["X-linked microtubule-associated protein, Mid1, regulates axon development"],"prefix":"10.1073","volume":"110","author":[{"given":"Tingjia","family":"Lu","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;"},{"name":"University of Chinese Academy of Sciences, Shanghai 200031, 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