{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:33:52Z","timestamp":1785569632629,"version":"3.56.0"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,6,18]]},"abstract":"<jats:p>\n                    Seronegative hepatitis\u2014non-A, non-B, non-C, non-D, non-E hepatitis\u2014is poorly characterized but strongly associated with serious complications. We collected 92 sera specimens from patients with non-A\u2013E hepatitis in Chongqing, China between 1999 and 2007. Ten sera pools were screened by Solexa deep sequencing. We discovered a 3,780-bp contig present in all 10 pools that yielded BLASTx E scores of 7e-05\u20130.008 against parvoviruses. The complete sequence of the\n                    <jats:italic>in silico<\/jats:italic>\n                    -assembled 3,780-bp contig was confirmed by gene amplification of overlapping regions over almost the entire genome, and the virus was provisionally designated NIH-CQV. Further analysis revealed that the contig was composed of two major ORFs. By protein BLAST, ORF1 and ORF2 were most homologous to the replication-associated protein of bat circovirus and the capsid protein of porcine parvovirus, respectively. Phylogenetic analysis indicated that NIH-CQV is located at the interface of\n                    <jats:italic>Parvoviridae<\/jats:italic>\n                    and\n                    <jats:italic>Circoviridae<\/jats:italic>\n                    . Prevalence of NIH-CQV in patients was determined by quantitative PCR. Sixty-three of 90 patient samples (70%) were positive, but all those from 45 healthy controls were negative. Average virus titer in the patient specimens was 1.05 e4 copies\/\u00b5L. Specific antibodies against NIH-CQV were sought by immunoblotting. Eighty-four percent of patients were positive for IgG, and 31% were positive for IgM; in contrast, 78% of healthy controls were positive for IgG, but all were negative for IgM. Although more work is needed to determine the etiologic role of NIH-CQV in human disease, our data indicate that a parvovirus-like virus is highly prevalent in a cohort of patients with non-A\u2013E hepatitis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1303744110","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T01:46:29Z","timestamp":1369791989000},"page":"10264-10269","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":50,"title":["Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing"],"prefix":"10.1073","volume":"110","author":[{"given":"Baoyan","family":"Xu","sequence":"first","affiliation":[{"name":"Hematology Branch and"},{"name":"Institute of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhi","sequence":"additional","affiliation":[{"name":"Hematology Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Systems Biology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wan","sequence":"additional","affiliation":[{"name":"Hematology Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Liu","sequence":"additional","affiliation":[{"name":"Hematology Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wong","sequence":"additional","affiliation":[{"name":"Hematology Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Kajigaya","sequence":"additional","affiliation":[{"name":"Hematology Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keji","family":"Zhao","sequence":"additional","affiliation":[{"name":"Systems Biology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal S.","family":"Young","sequence":"additional","affiliation":[{"name":"Hematology Branch and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/hep.1840090617","article-title":"Hepatitis A virus: Insights from molecular biology","volume":"9","author":"Cohen JI","year":"1989","unstructured":"JI Cohen, Hepatitis A virus: Insights from molecular biology. 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