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Members of the Nematoda are heme auxotrophs, lacking the ability to synthesize heme; however, the human filarial parasite\n                    <jats:italic>Brugia malayi<\/jats:italic>\n                    has acquired a bacterial gene encoding ferrochelatase (BmFeCH), the terminal step in heme biosynthesis. BmFeCH, encoded by a 9-exon gene, is a mitochondrial-targeted, functional ferrochelatase based on enzyme assays, complementation, and inhibitor studies. Homologs have been identified in several filariae and a nonfilarial nematode. RNAi and ex vivo inhibitor experiments indicate that BmFeCH is essential for viability, validating it as a potential target for filariasis control.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1304049110","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T03:10:22Z","timestamp":1366686622000},"page":"7748-7753","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":54,"title":["Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes"],"prefix":"10.1073","volume":"110","author":[{"given":"Bo","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Molecular Parasitology, New England Biolabs, Inc., Ipswich, MA 01938;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Novelli","sequence":"additional","affiliation":[{"name":"Division of Molecular Parasitology, New England Biolabs, Inc., Ipswich, MA 01938;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daojun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Developmental Biology Department, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry A.","family":"Dailey","sequence":"additional","affiliation":[{"name":"Biomedical and Health Sciences Institute, Department of Microbiology, and"},{"name":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Landmann","sequence":"additional","affiliation":[{"name":"Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Ford","sequence":"additional","affiliation":[{"name":"Parasitology Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Parasitology Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clotilde K. 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