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These findings underscore the fact that investigating mouse models under a single set of environmental temperature conditions may lead to a misunderstanding of the antitumor immune potential. These data also highlight the need for additional study to determine how systemic metabolic stress modulates the functions of immune effector cells, particularly in tumor-bearing mice, and whether cancer therapies, including immunotherapy, are impacted by housing temperature.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1304291110","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:49:39Z","timestamp":1384818579000},"page":"20176-20181","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":308,"title":["Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature"],"prefix":"10.1073","volume":"110","author":[{"given":"Kathleen M.","family":"Kokolus","sequence":"first","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maegan L.","family":"Capitano","sequence":"additional","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Ting","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.-L.","family":"Eng","sequence":"additional","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Waight","sequence":"additional","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie L.","family":"Hylander","sequence":"additional","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sexton","sequence":"additional","affiliation":[{"name":"Department of Animal Resources, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27709"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott I.","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Repasky","sequence":"additional","affiliation":[{"name":"Department of Immunology,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"4227","article-title":"Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models","volume":"9","author":"Voskoglou-Nomikos T","year":"2003","unstructured":"T Voskoglou-Nomikos, JL Pater, L Seymour, Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. 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