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We previously showed that the transcription factor BACH1 is negatively regulated by RKIP and promotes breast cancer metastasis. Here we reveal a network architecture between the metastasis suppressor RKIP and the metastasis promoter BACH1 that enables single cells to generate a stable subpopulation of prometastatic cells without any genetic changes.<\/jats:p>","DOI":"10.1073\/pnas.1304840111","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T23:30:23Z","timestamp":1389051023000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":93,"title":["Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions"],"prefix":"10.1073","volume":"111","author":[{"given":"Jiyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Systems Biology\u2013Unit 950, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Farquhar","sequence":"additional","affiliation":[{"name":"Department of Systems Biology\u2013Unit 950, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Yun","sequence":"additional","affiliation":[{"name":"Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637;"},{"name":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon 363-883, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey A.","family":"Frankenberger","sequence":"additional","affiliation":[{"name":"Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cancer Biology, The University of Toledo, Toledo, OH 43606; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, University of Sheffield, Sheffield S3 7RH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Bal\u00e1zsi","sequence":"additional","affiliation":[{"name":"Department of Systems Biology\u2013Unit 950, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha Rich","family":"Rosner","sequence":"additional","affiliation":[{"name":"Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3327"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2556"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3261"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.027"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160165"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","unstructured":"Gupta PB et al. 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