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We show that IFN-\u03b3 signaling regulates enzymes involved in melanin biosynthesis through a transcription factor IFN regulatory factor-1. Our study identifies a new mechanism of skin pigmentation homeostasis and proposes that strength and durability of local skin immune response may be decisive factors to delineate outcome between skin tanning and cancer.<\/jats:p>","DOI":"10.1073\/pnas.1304988111","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T20:17:41Z","timestamp":1390940261000},"page":"2301-2306","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":109,"title":["IFN-\u03b3 signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation"],"prefix":"10.1073","volume":"111","author":[{"given":"Vivek T.","family":"Natarajan","sequence":"first","affiliation":[{"name":"Council for Scientific and Industrial Research - Institute of Genomics and Integrative Biology, Delhi 110007, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Ganju","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Singh","sequence":"additional","affiliation":[{"name":"Council for Scientific and Industrial Research - Institute of Genomics and Integrative Biology, Delhi 110007, India;"},{"name":"National Institute of Immunology, New Delhi 110067, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinaya","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Chemical Engineering Division, Council for Scientific and Industrial Research - National Chemical Laboratory, Pune, Maharashtra 411008, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritika","family":"Kirty","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Yadav","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Puntambekar","sequence":"additional","affiliation":[{"name":"Chemical Engineering Division, Council for Scientific and Industrial Research - National Chemical Laboratory, Pune, Maharashtra 411008, India;"},{"name":"Academy of Scientific and Innovative Research, New Delhi 110001, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi 110001, India; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi P.","family":"Dani","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemanta K.","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi 110001, India; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan J.","family":"Gadgil","sequence":"additional","affiliation":[{"name":"Council for Scientific and Industrial Research - Institute of Genomics and Integrative Biology, Delhi 110007, India;"},{"name":"Chemical Engineering Division, Council for Scientific and Industrial Research - National Chemical Laboratory, Pune, Maharashtra 411008, India;"},{"name":"Academy of Scientific and Innovative Research, New Delhi 110001, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamurthy","family":"Natarajan","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Rani","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, New Delhi 110067, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh S.","family":"Gokhale","sequence":"additional","affiliation":[{"name":"Council for Scientific and Industrial Research - Institute of Genomics and Integrative Biology, Delhi 110007, India;"},{"name":"National Institute of Immunology, New Delhi 110067, India;"},{"name":"Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka 560064, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrm2636","article-title":"Epidermal homeostasis: A balancing act of stem cells in the skin","volume":"10","author":"Blanpain C","year":"2009","unstructured":"C Blanpain, E Fuchs, Epidermal homeostasis: A balancing act of stem cells in the skin. 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