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These pathways involve differentially acting downstream constituents, including protein kinase C\u03b3, brain-derived neurotrophic factor, and a voltage-dependent anion channel. The metabolic mechanisms established here may apply to the development and degeneration of PNs and additional types of neurons in many animal and human brain diseases in which PNs are notably vulnerable.<\/jats:p>","DOI":"10.1073\/pnas.1305010110","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:11:55Z","timestamp":1368576715000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["Tissue plasminogen activator regulates Purkinje neuron development and survival"],"prefix":"10.1073","volume":"110","author":[{"given":"Jianxue","family":"Li","sequence":"first","affiliation":[{"name":"Departments of aNeurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Boston University Medical School, Boston, MA 02118;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Gu","sequence":"additional","affiliation":[{"name":"Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"David H. 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