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Amylin-induced membrane disruption has attracted considerable interest, and the interactions of amylin with model membranes have been characterized, but the relationship between studies with model membranes and toxicity is not understood. In this article the relationship between cell toxicity and the ability to disrupt model membranes is examined. There is no direct correlation between the two processes.<\/jats:p>","DOI":"10.1073\/pnas.1305517110","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T23:48:45Z","timestamp":1384213725000},"page":"19279-19284","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":144,"title":["Islet amyloid polypeptide toxicity and membrane interactions"],"prefix":"10.1073","volume":"110","author":[{"given":"Ping","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andisheh","family":"Abedini","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, New York University School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Hsien","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Diabetes Research Program, New York University School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Raleigh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1104-1054"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.101304.123901"},{"key":"e_1_3_3_3_2","first-page":"151","article-title":"Islet amyloid, increased alpha-cells, reduced beta-cells and exocrine fibrosis: Quantitative changes in the pancreas in type-2 diabetes","volume":"9","author":"Clark A","year":"1988","unstructured":"A Clark, et al., Islet amyloid, increased alpha-cells, reduced beta-cells and exocrine fibrosis: Quantitative changes in the pancreas in type-2 diabetes. 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