{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:31:21Z","timestamp":1781105481897,"version":"3.54.1"},"reference-count":47,"publisher":"National Academy of Sciences","issue":"37","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2013,9,10]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    We describe a genomic disorder that causes obesity, intellectual disability, and seizures. Children with this syndrome carry an unbalanced chromosome translocation that results in the duplication of over 100 genes, including\n                    <jats:italic>G protein \u03b23<\/jats:italic>\n                    (\n                    <jats:italic>GNB3<\/jats:italic>\n                    ). Although\n                    <jats:italic>GNB3<\/jats:italic>\n                    polymorphisms have been associated with obesity, hypertension, and diabetes, the mechanism of\n                    <jats:italic>GNB3<\/jats:italic>\n                    pathogenesis is unknown. We created a transgenic mouse model that carries a duplication of\n                    <jats:italic>GNB3<\/jats:italic>\n                    , weighs significantly more than wild-type mice, and has excess abdominal fat.\n                    <jats:italic>GNB3<\/jats:italic>\n                    is highly expressed in the brain and may be important for signaling related to satiety and\/or metabolism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1305999110","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T22:24:39Z","timestamp":1377555879000},"page":"14990-14994","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["Mouse model implicates\n                    <i>GNB3<\/i>\n                    duplication in a childhood obesity syndrome"],"prefix":"10.1073","volume":"110","author":[{"given":"Ian S.","family":"Goldlust","sequence":"first","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Hermetz","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Barfield","sequence":"additional","affiliation":[{"name":"Departments of bBiostatistics and Bioinformatics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Cozad","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Wynn","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alev Cagla","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen N.","family":"Conneely","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"},{"name":"Departments of bBiostatistics and Bioinformatics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G.","family":"Mulle","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"},{"name":"Epidemiology, Emory University School of Public Health, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Dharamrup","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri R.","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60614;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Angle","sequence":"additional","affiliation":[{"name":"Division of Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60614;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Colley","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, South Western Sydney Local Health District, Liverpool, NSW 1871, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Webb","sequence":"additional","affiliation":[{"name":"Amy E. Webb Pediatrics, Pismo Beach, CA 93449;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C.","family":"Thorland","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay W.","family":"Ellison","sequence":"additional","affiliation":[{"name":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, WA 99207;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill A.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, WA 99207;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake C.","family":"Ballif","sequence":"additional","affiliation":[{"name":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, WA 99207;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, WA 99207;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie A.","family":"Demmer","sequence":"additional","affiliation":[{"name":"Division of Genetics and Metabolism, Tufts University School of Medicine, Boston, MA 02111; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Unique Rare Chromosome Disorder Support Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Katharine","family":"Rudd","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly A","family":"Searle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112464"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005243222102"},{"key":"e_1_3_3_3_2","first-page":"1243","article-title":"The genetic and environmental sources of body mass index variability: The Muscatine Ponderosity Family Study","volume":"49","author":"Moll PP","year":"1991","unstructured":"PP Moll, TL Burns, RM Lauer, The genetic and environmental sources of body mass index variability: The Muscatine Ponderosity Family Study. Am J Hum Genet 49, 1243\u20131255 (1991).","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05880.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920211795677921"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.274"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.287"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.686"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2247"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ef4286"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08689"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08727"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.09.014"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2607"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429772"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/43185"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411204"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00840.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3757"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.07.004"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq317"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002713"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.032"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/341610"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32516"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.111609.110"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr293"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-5-6"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.145631.112"},{"key":"e_1_3_3_31_2","first-page":"375","article-title":"Overgrowth syndromes:from classical to new","volume":"6","author":"Visser R","year":"2009","unstructured":"R Visser, SG Kant, JM Wit, MH Breuning, Overgrowth syndromes:from classical to new. Pediatr Endocrinol Rev 6, 375\u2013394 (2009).","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.157693"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283491153"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-45"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201334"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320550414"},{"key":"e_1_3_3_37_2","first-page":"224","article-title":"Clinical and cytogenetic studies in a large (4;8) translocation family with pre- and postnatal Wolf syndrome","volume":"27","author":"Tranebjaerg L","year":"1984","unstructured":"L Tranebjaerg, A Petersen, K Hove, H Rehder, M Mikkelsen, Clinical and cytogenetic studies in a large (4;8) translocation family with pre- and postnatal Wolf syndrome. Ann Genet 27, 224\u2013229 (1984).","journal-title":"Ann Genet"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2008.0109"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.010"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.909"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31822c79f9"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31143"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35400"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2009.04.003"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-242"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.40"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.4.761"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1305999110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T21:49:03Z","timestamp":1649800143000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1305999110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,26]]},"references-count":47,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2013,9,10]]}},"alternative-id":["10.1073\/pnas.1305999110"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1305999110","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,26]]},"assertion":[{"value":"2013-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}