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We describe a unique signaling pathway driven by TGF-\u03b2, which acutely dysregulates ENaC trafficking, blocking alveolar Na\n                    <jats:sup>+<\/jats:sup>\n                    transport and edema resolution. This pathway represents a unique pathomechanism in ARDS, highlights potential \u201cdruggable\u201d targets, and may represent a physiological means of acutely regulating ENaC in lungs and other organs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1306798111","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:11:29Z","timestamp":1386634289000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":121,"title":["TGF-\u03b2 directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury"],"prefix":"10.1073","volume":"111","author":[{"given":"Dorothea M.","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Vad\u00e1sz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Wujak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"},{"name":"Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Wygrecka","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Justus Liebig University, Universities of Giessen and Marburg Lung Center, German Center for Lung Research, 35392 Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Olschewski","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology,"},{"name":"Ludwig Boltzmann Institute for Lung Vascular Research, Medical University of Graz, 8010 Graz, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Papp","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Lung Vascular Research, Medical University of Graz, 8010 Graz, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rummel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph P.","family":"Brandes","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Physiology, Goethe University Frankfurt, 60590 Frankfurt, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Waldegger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Philipps University Marburg, 35032 Marburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Eickelberg","sequence":"additional","affiliation":[{"name":"Institute of Lung Biology and Disease, Helmholtz Zentrum Munich, German Center for Lung Research, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Seeger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"},{"name":"Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory E.","family":"Morty","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,"},{"name":"Department of Lung Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2013,12,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"e_1_3_3_2_2","first-page":"375","article-title":"What makes a good lung?","volume":"139","author":"Weibel ER","year":"2009","unstructured":"ER Weibel, What makes a good lung? 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